Achilles tendon structure is negatively correlated with body mass index, but not influenced by statin use: A cross-sectional study using ultrasound tissue characterization.
Achilles tendon structure is negatively correlated with body mass index, but not influenced by statin use: A cross-sectional study using ultrasound tissue characterization.
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DOI：
10.1371/journal.pone.0199645
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Scott A
中科院分区：
文献类型：
--
作者：
de Sá A;Hart DA;Khan K;Scott A
他汀类药物被广泛用于抑制高胆固醇血症患者肝脏中胆固醇的产生。英国最近的一项流行病学研究表明，他汀类药物的使用(与BMI升高不同)与跟腱断裂风险的增加无关。然而，由于实验室报告显示他汀类药物对腱细胞代谢有负面影响，我们决定直接比较经常使用他汀类药物的患者和不使用他汀类药物的患者的跟腱结构(横截面面积和纵向胶原组织)。我们对他汀类药物使用者和年龄和性别相近的对照组进行了跟腱超声组织定征(UTC)。从2015年5月10日至2017年2月17日，通过心血管健康中心和普通社区招募了他汀类药物使用者和对照组参与者。在预定的位置(距跟骨近端2厘米)，盲人观察者使用定量超声组织定征来评估跟腱横截面积和纵向胶原组织(%I型回声)。66名服用他汀类药物至少一年的患者(ST，n=33)或从未服用他汀类药物的对照组(CG，n=33)被纳入研究。两组跟腱横截面积(ST59.7(13)mm2，CG 59.9(8.5)mm2)和I型回声的比例[ST70(10)%，CG 74(13)%]相当。相反，体重指数与I型回声呈负相关(r=-0.25，p=0.042)。肥胖者的I型回声百分率(62(11)%)显著低于体重指数正常者(73(10)%p<；0.05)。这些发现表明，没有证据表明他汀类药物对跟腱结构有负面影响。鉴于早些时候有报道称，服用他汀类药物的人和不使用他汀类药物的人发生跟腱损伤的风险相当，可以在不将跟腱置于比普通人群更高的受伤风险的情况下，开出负重运动处方。这项研究的结果与已知的BMI升高对肌腱结构的负面影响是一致的，这表明在肥胖者进行负重锻炼之前对跟腱进行评估可能是谨慎的。
Statins are widely used to inhibit cholesterol production in the liver among people with hypercholesterolemia. A recent epidemiological study in the UK has shown that statin use (unlike elevated BMI) is not associated with an increased risk of Achilles tendon rupture. However, because of laboratory reports suggesting a negative influence of statins on tenocyte metabolism, we decided to directly compare the Achilles tendon structure (cross-sectional area and longitudinal collagen organization) in regular statin users compared to non-users. We conducted ultrasound tissue characterization (UTC) of the Achilles tendon in statin users and a comparison group of similar age and gender. Statin users and control participants were recruited from May 10 2015 to February 17 2017 through a cardiovascular health centre and from the general community. Cross-sectional area of the Achilles tendon and longitudinal collagen organization (% type I echoes) were assessed using quantitative ultrasound tissue characterization by a blinded observer at a predetermined location (2 cm proximal to the calcaneus). Sixty-six individuals who were either taking statins for at least one year (ST, n = 33) or a comparison group who had never taken statins (CG, n = 33) were included in the study. The Achilles tendon cross-sectional area (ST 59.7 (13) mm2, CG 59.9 (8.5) mm2) and proportion of echo-type I patterns [ST 70 (10)%, CG 74 (13)%] were equivalent in the two groups. In contrast, there was a negative correlation between BMI (rs = -0.25, p = 0.042) and type I echo values. Obese individuals demonstrated a significantly lower percentage of type I echoes (62 (11)%) than individuals of normal body mass index (73 (10)% p<0.05). These findings demonstrate that there is no evidence of a negative statin influence on Achilles tendon structure. Given earlier reports that the risk of Achilles injury is equivalent in statin users and non-users, weightbearing exercise may be prescribed without placing the Achilles tendon at a higher risk of injury than among the general population. The results of this study are consistent with the known negative effects of elevated BMI on tendon structure, suggesting that an assessment of the Achilles tendons prior to prescribing weightbearing exercise may be prudent in obese individuals.
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影响因子：
18.4
作者：
Scott A;Zwerver J;Grewal N;de Sa A;Alktebi T;Granville DJ;Hart DA
通讯作者：
Hart DA
影响因子：
3.7
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