Stimulation of the nucleus accumbens as behavioral reward in awake behaving monkeys.
Stimulation of the nucleus accumbens as behavioral reward in awake behaving monkeys.
复制标题
DOI：
10.1016/j.jneumeth.2011.05.025
复制
发表时间：
2011-08-15
影响因子：
3
通讯作者：
Desimone, Robert
中科院分区：
文献类型：
--
作者：
Bichot, Narcisse P.;Heard, Matthew T.;Desimone, Robert
人们已经知道，猴子会反复按压一根棒，在几个不同的大脑结构中进行电刺激。我们探索了在这样一个结构中使用电刺激的可能性，即在执行复杂任务（即视觉搜索）的动物中，将神经核作为液体奖励的替代品。在使用刺激来激励动物的日子里，动物在笼中的任何时候都可以完全接触到水。电刺激被传递到两侧的镜像位置和周围的反射镜，动物的动机工作的电刺激是量化的试验，他们每单位时间正确执行的数量。急性映射显示，在一个大面积的刺激成功地支持在任务期间的行为表现。性能随着电流的增加而提高，直到达到理论上的最大渐近水平。此外，长期植入电极的刺激表明，动物为电刺激而工作的动机至少相当于，而且往往比在水控制下为液体奖励而工作时更好。这些结果表明，在复杂的任务中，电刺激小脑是一种可行的奖励方法。由于这种奖励方法不需要控制水或食物的摄入量，它可以提供一种替代传统的液体或食物奖励猴子，这取决于特定研究项目的目标和要求。
It has been known that monkeys will repeatedly press a bar for electrical stimulation in several different brain structures. We explored the possibility of using electrical stimulation in one such structure, the nucleus accumbens, as a substitute for liquid reward in animals performing a complex task, namely visual search. The animals had full access to water in the cage at all times on days when stimulation was used to motivate them. Electrical stimulation was delivered bilaterally at mirror locations in and around the accumbens, and the animals’ motivation to work for electrical stimulation was quantified by the number of trials they performed correctly per unit of time. Acute mapping revealed that stimulation over a large area successfully supported behavioral performance during the task. Performance improved with increasing currents until it reached an asymptotic, theoretically maximal level. Moreover, stimulation with chronically-implanted electrodes showed that an animal’s motivation to work for electrical stimulation was at least equivalent to, and often better than, when it worked for liquid reward while on water control. These results suggest that electrical stimulation in the accumbens is a viable method of reward in complex tasks. Because this method of reward does not necessitate control over water or food intake, it may offer an alternative to the traditional liquid or food rewards in monkeys, depending on the goals and requirements of the particular research project.
登录
查看更多内容
影响因子：
2.9
作者：
ROLLS, ET;BURTON, MJ;MORA, F
通讯作者：
MORA, F
影响因子：
3.3
作者：
LYNDBALTA, E;HABER, SN
通讯作者：
HABER, SN
影响因子：
2
作者：
Nowak, LG;Bullier, J
通讯作者：
Bullier, J
影响因子：
3
作者：
Prescott, Mark J.;Brown, Verity J.;Whitfield, Lucy
通讯作者：
Whitfield, Lucy
影响因子：
5.3
作者：
ROUTTENBERG, A;GARDNER, EL;HUANG, YH
通讯作者：
HUANG, YH