Equine-Like H3 Avian Influenza Viruses in Wild Birds, Chile.
Equine-Like H3 Avian Influenza Viruses in Wild Birds, Chile.
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智利野生鸟类中的马样H3禽流感病毒。
DOI：
10.3201/eid2612.202063
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发表时间：
2020-12
影响因子：
11.8
通讯作者：
Hamilton-West C
中科院分区：
文献类型：
--
作者：
Bravo-Vasquez N;Yao J;Jimenez-Bluhm P;Meliopoulos V;Freiden P;Sharp B;Estrada L;Davis A;Cherry S;Livingston B;Danner A;Schultz-Cherry S;Hamilton-West C
自1963年在美国发现以来，马流感病毒（H3N8）感染的爆发与全球马的严重呼吸道疾病有关。基因组分析表明，马H3病毒属于禽类谱系，可能起源于野生鸟类。从南美洲南锥体野生鸟类中分离出的禽流感病毒中已经鉴定出类似马的内部基因。然而，马样H3血凝素尚未确定。我们从智利野生鸟类中分离出6种不同的H3病毒，这些病毒具有血凝素、核蛋白、非结构蛋白1和聚合酶酸性基因，与1963年H3N8马流感病毒谱系具有高度核苷酸同源性。尽管核苷酸相似，但来自智利的病毒在抗原性上与禽类病毒更密切相关，并在鸡中有效传播，表明适应了禽类宿主。这些研究提供了马样H3血凝素继续在野生鸟类水库循环的初步证明。
Since their discovery in the United States in 1963, outbreaks of infection with equine influenza virus (H3N8) have been associated with serious respiratory disease in horses worldwide. Genomic analysis suggests that equine H3 viruses are of an avian lineage, likely originating in wild birds. Equine-like internal genes have been identified in avian influenza viruses isolated from wild birds in the Southern Cone of South America. However, an equine-like H3 hemagglutinin has not been identified. We isolated 6 distinct H3 viruses from wild birds in Chile that have hemagglutinin, nucleoprotein, nonstructural protein 1, and polymerase acidic genes with high nucleotide homology to the 1963 H3N8 equine influenza virus lineage. Despite the nucleotide similarity, viruses from Chile were antigenically more closely related to avian viruses and transmitted effectively in chickens, suggesting adaptation to the avian host. These studies provide the initial demonstration that equine-like H3 hemagglutinin continues to circulate in a wild bird reservoir.
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DOI：
10.1093/bioinformatics/btq706
发表时间：
2011-02-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Schliep KP
通讯作者：
Schliep KP
影响因子：
4.4
作者：
Joseph U;Su YC;Vijaykrishna D;Smith GJ
通讯作者：
Smith GJ
影响因子：
13.2
作者：
Jimenez-Bluhm, Pedro;Bravo-Vasquez, Nicolas;Hamilton-West, Christopher
通讯作者：
Hamilton-West, Christopher
影响因子：
1.4
作者：
Spackman, Erica;McCracken, Kevin G.;Swayne, David E.
通讯作者：
Swayne, David E.
影响因子：
6.7
作者：
Bahl J;Krauss S;Kühnert D;Fourment M;Raven G;Pryor SP;Niles LJ;Danner A;Walker D;Mendenhall IH;Su YC;Dugan VG;Halpin RA;Stockwell TB;Webby RJ;Wentworth DE;Drummond AJ;Smith GJ;Webster RG
通讯作者：
Webster RG