Growth inhibitory effect of low fat diet on prostate cancer cells: results of a prospective, randomized dietary intervention trial in men with prostate cancer.
Growth inhibitory effect of low fat diet on prostate cancer cells: results of a prospective, randomized dietary intervention trial in men with prostate cancer.
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DOI：
10.1016/j.juro.2009.08.104
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发表时间：
2010-01
期刊：
影响因子：
--
通讯作者：
Kobayashi N
中科院分区：
文献类型：
--
作者：
Aronson WJ;Barnard RJ;Freedland SJ;Henning S;Elashoff D;Jardack PM;Cohen P;Heber D;Kobayashi N
高脂肪的西方饮食和久坐的生活方式可能会通过血清激素和生长因子的变化使男性易患前列腺癌。我们通过对前列腺癌患者进行前瞻性、随机饮食干预试验，评估了低脂饮食对影响前列腺癌细胞生长的血清因子的影响。我们将18名先前未接受治疗的前列腺癌患者随机分为低脂（15%千卡）、高纤维、大豆蛋白补充饮食或西式（40%千卡脂肪）饮食4周。在基线和干预后收集空腹血清，以测量前列腺特异性抗原、性激素、胰岛素、胰岛素样生长因子I和II、胰岛素样生长因子结合蛋白、脂质和脂肪酸。在含有干预前和干预后人血清的培养基中培养LNCaP细胞（ATCC®），以评估饮食对前列腺癌细胞增殖的体外作用。各组受试者均高度依从饮食干预。相对于西方饮食血清，来自低脂组中的男性的血清显著降低LNCaP细胞的生长（p = 0.03）。血清前列腺特异性抗原、性激素、胰岛素、胰岛素样生长因子I和II以及胰岛素样生长因子结合蛋白在组间无显著变化。低脂组的血清甘油三酯和亚油酸（ω-6）水平降低（分别为p = 0.034和0.005）。相关性分析显示，ω-6脂肪酸减少和ω-3脂肪酸增加与血清刺激的LNCaP细胞生长减少相关（分别为r = 0.64，p = 0.004和r =-0.49，p = 0.04）。在这项前瞻性随机饮食干预试验中，低脂饮食导致血清脂肪酸水平的变化，这与人类LNCaP癌细胞生长减少有关。进一步的前瞻性试验表明，以评估潜在的低脂肪饮食的前列腺癌的预防和治疗。
A high fat Western diet and sedentary lifestyle may predispose men to prostate cancer through changes in serum hormones and growth factors. We evaluated the effect of a low fat diet on serum factors affecting prostate cancer cell growth by performing a prospective, randomized dietary intervention trial in men with prostate cancer. We randomized 18 men with prostate cancer who did not receive prior therapy to a low fat (15% kcal), high fiber, soy protein supplemented diet or a Western (40% kcal fat) diet for 4 weeks. Fasting serum was collected at baseline and after the intervention to measure prostate specific antigen, sex hormones, insulin, insulin-like growth factor I and II, insulin-like growth factor binding proteins, lipids and fatty acids. LNCaP cells (ATCC®) were cultured in medium containing pre-intervention and post-intervention human serum to assess the in vitro effect of the diet on prostate cancer cell proliferation. Subjects in each group were highly compliant with the dietary intervention. Serum from men in the low fat group significantly decreased the growth of LNCaP cells relative to Western diet serum (p = 0.03). There were no significant between group changes in serum prostate specific antigen, sex hormones, insulin, insulin-like growth factor I and II, and insulin-like growth factor binding proteins. Serum triglyceride and linoleic acid (ω-6) levels were decreased in the low fat group (p = 0.034 and 0.005, respectively). Correlation analysis revealed that decreased ω-6 and increased ω-3 fatty acid correlated with decreased serum stimulated LNCaP cell growth (r = 0.64, p = 0.004 and r = −0.49, p = 0.04, respectively). In this prospective, randomized dietary intervention trial a low fat diet resulted in changes in serum fatty acid levels that were associated with decreased human LNCaP cancer cell growth. Further prospective trials are indicated to evaluate the potential of low fat diets for prostate cancer prevention and treatment.
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影响因子：
8.8
作者：
Allen, N. E.;Key, T. J.;Appleby, P. N.;Travis, R. C.;Roddam, A. W.;Tjonneland, A.;Johnsen, N. F.;Overvad, K.;Linseisen, J.;Rohrmann, S.;Boeing, H.;Pischon, T.;Bueno-de-Mesquita, H. B.;Kiemeney, L.;Tagliabue, G.;Palli, D.;Vineis, P.;Tumino, R.;Trichopoulou, A.;Kassapa, C.;Trichopoulos, D.;Ardanaz, E.;Larranaga, N.;Tormo, M-J;Gonzalez, C. A.;Quiros, J. R.;Sanchez, M-J;Bingham, S.;Khaw, K-T;Manjer, J.;Berglund, G.;Stattin, P.;Hallmans, G.;Slimani, N.;Ferrari, P.;Rinaldi, S.;Riboli, E.
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