Developing Novel Biointerfaces: Using Chlorhexidine Surface Attachment as a Method for Creating Anti-Fungal Surfaces.
Developing Novel Biointerfaces: Using Chlorhexidine Surface Attachment as a Method for Creating Anti-Fungal Surfaces.
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DOI：
10.1002/gch2.202100138
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发表时间：
2022-05
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在医疗保健环境中，人们越来越关注对抗抗菌素耐药性感染。虽然细菌感染得到了很好的报道，但真菌引起的感染受到的关注较少，但对社会有广泛的影响，并且可能是致命的。真菌是真核生物，与人类有相当多的共同生物学，因此，有限的技术存在，以打击真菌感染和医院基础设施很少被设计为减少微生物负荷。在这项研究中，报道了一种新型的抗菌表面（AMS），该表面用广谱杀生物剂氯己定修饰。所述表面显示出非常快速地（<15分钟）杀死机会性真菌病原体白色念珠菌和新型隐球菌，并且比商业市场上可获得的当前技术（例如银和铜）显著更有效。疾病传播是一个全球性问题。在目前的气候下，空气传播是一个重要的重点。然而，在许多感染中，表面在传播中起着关键作用。本研究证明了抗微生物表面技术在杀灭机会性真菌病原体方面的功效。
There is an increasing focus in healthcare environments on combatting antimicrobial resistant infections. While bacterial infections are well reported, infections caused by fungi receive less attention, yet have a broad impact on society and can be deadly. Fungi are eukaryotes with considerable shared biology with humans, therefore limited technologies exist to combat fungal infections and hospital infrastructure is rarely designed for reducing microbial load. In this study, a novel antimicrobial surface (AMS) that is modified with the broad‐spectrum biocide chlorhexidine is reported. The surfaces are shown to kill the opportunistic fungal pathogens Candida albicans and Cryptococcus neoformans very rapidly (<15 min) and are significantly more effective than current technologies available on the commercial market, such as silver and copper. Transmission of disease is a global problem. In the current climate, there is a significant focus on airborne transmission. However, in many infections, surfaces play a key role in transmission. The present study demonstrates the efficacy of an antimicrobial surface technology in killing opportunistic fungal pathogens.
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