The roles of NFE2L1 in adipocytes: Structural and mechanistic insight from cell and mouse models.
The roles of NFE2L1 in adipocytes: Structural and mechanistic insight from cell and mouse models.
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DOI：
10.1016/j.redox.2021.102015
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发表时间：
2021-08
期刊：
影响因子：
11.4
通讯作者：
Pi J
中科院分区：
文献类型：
--
作者：
Ren S;Bian Y;Hou Y;Wang Z;Zuo Z;Liu Z;Teng Y;Fu J;Wang H;Xu Y;Zhang Q;Chen Y;Pi J
脂肪细胞通过在脂肪组织（AT）中储存脂质，根据机体的能量需求调节AT与循环之间的脂质通量，并分泌多种激素、细胞因子等因素，在维持能量稳态中发挥关键作用。适当的AT发育和功能确保整体代谢健康。核因子红系2相关因子1 （Nuclear factor erythroid 2-related factor 1, NFE2L1，又称NRF1）属于nc - bzip家族，在多种细胞和组织的多种基本细胞功能调控和应激反应中发挥关键作用。人类和啮齿类动物的Nfe2l1基因可以转录成多种剪接变体，从而产生各种蛋白质异构体，这些异构体可以通过各种翻译后机制进一步修饰。虽然NFE2L1的长异构体已被确定为细胞适应性抗氧化反应和蛋白酶体稳态的主要调节因子，但NFE2L1的确切组织分布和生理功能，特别是短异构体，仍在深入研究中。关于NFE2L1在脂肪细胞中的关键作用，新出现的数据表明，缺乏NFE2L1会导致脂肪生成异常和AT功能受损。有趣的是，人类NFE2L1基因的单核苷酸多态性（SNP）与肥胖有关。在这篇综述中，我们总结了关于NFE2L1的多个亚型在AT形成和功能中的具体作用的最重要的发现。我们强调，NFE2L1在多个基因的表达中起着基本的调节作用，这些基因对AT代谢和功能至关重要，因此可能是改善涉及异常脂肪可塑性和脂质稳态的疾病状态的重要靶点。
Adipocytes play pivotal roles in maintaining energy homeostasis by storing lipids in adipose tissue (AT), regulating the flux of lipids between AT and the circulation in response to the body's energy requirements and secreting a variety of hormones, cytokines and other factors. Proper AT development and function ensure overall metabolic health. Nuclear factor erythroid 2-related factor 1 (NFE2L1, also known as NRF1) belongs to the CNC-bZIP family and plays critical roles in regulating a wide range of essential cellular functions and varies stress responses in many cells and tissues. Human and rodent Nfe2l1 genes can be transcribed into multiple splice variants resulting in various protein isoforms, which may be further modified by a variety of post-translational mechanisms. While the long isoforms of NFE2L1 have been established as master regulators of cellular adaptive antioxidant response and proteasome homeostasis, the exact tissue distribution and physiological function of NFE2L1 isoforms, the short isoforms in particular, are still under intense investigation. With regard to key roles of NFE2L1 in adipocytes, emerging data indicates that deficiency of Nfe2l1 results in aberrant adipogenesis and impaired AT functioning. Intriguingly, a single nucleotide polymorphism (SNP) of the human NFE2L1 gene is associated with obesity. In this review, we summarize the most significant findings regarding the specific roles of the multiple isoforms of NFE2L1 in AT formation and function. We highlight that NFE2L1 plays a fundamental regulatory role in the expression of multiple genes that are crucial to AT metabolism and function and thus could be an important target to improve disease states involving aberrant adipose plasticity and lipid homeostasis.
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影响因子：
5.2
作者：
Choe SS;Huh JY;Hwang IJ;Kim JI;Kim JB
通讯作者：
Kim JB
脂肪细胞特异性 Nfe2l1 缺陷会破坏小鼠白色脂肪组织的可塑性和代谢稳态
DOI：
10.1016/j.bbrc.2018.06.013
发表时间：
2018-09-03
影响因子：
3.1
作者：
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通讯作者：
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影响因子：
82.9
作者：
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Hotamisligil GS
影响因子：
14.9
作者：
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通讯作者：
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影响因子：
7.4
作者：
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通讯作者：
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