Steroid hormone agonists reduce female fitness in insecticide-resistant Anopheles populations
Steroid hormone agonists reduce female fitness in insecticide-resistant Anopheles populations
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类固醇激素激动剂降低了抗药性按蚊种群中的雌性健康水平
DOI：
10.1101/2020.02.14.949024
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Brown F
中科院分区：
文献类型：
--
作者：
Brown F
以杀虫剂为基础的病媒控制工具，如经杀虫剂处理的蚊帐和室内滞留喷洒，是疟疾控制规划的基石。对这些规划中使用的化学品的耐药性现在很普遍，对减少疟疾相关发病率和死亡率方面取得的成果构成了重大威胁。最近，在实验室易感冈比亚按蚊种群中，20-羟基蜕皮激素类固醇激素通路的破坏被证明会减少疟原虫的发育，并显着降低寿命和产卵量。在这里，我们证明了通过应用二苯甲酰肼，甲氧基虫酰肼（DBH-M）来破坏这一途径。coluzzii,。冈比亚按蚊slandAn。真菌种群在局部和大面积应用中显著降低产蛋量。此外，DBH-M在局部使用时，以及在血液喂养后，会降低成年人的寿命。由于细胞色素p450在拟除虫菊酯类抗性果蝇中升高，仅与DBH-M结合非常弱，因此该化合物不太可能在野外环境中产生交叉抗性。因此，操纵这一激素信号通路是对当前疟疾控制战略的一种潜在补充方法，特别是在杀虫剂耐药性高、危及现有工具的地区。
Insecticide based vector control tools such as insecticide treated bednets and indoor residual spraying represent the cornerstones of malaria control programs. Resistance to chemistries used in these programs is now widespread and represents a significant threat to the gains seen in reducing malaria-related morbidity and mortality. Recently, disruption of the 20-hydroxyecdysone steroid hormone pathway was shown to reducePlasmodiumdevelopment and significantly reduce both longevity and egg production in a laboratory susceptibleAnopheles gambiaepopulation. Here, we demonstrate that disruption of this pathway by application of the dibenzoylhydrazine, methoxyfenozide (DBH-M), to insecticide resistantAn. coluzzii,An. gambiae slandAn. funestuspopulations significantly reduces egg production in both topical and tarsal application. Moreover, DBH-M reduces adult longevity when applied topically, and tarsally after blood feeding. As the cytochrome p450s elevated in pyrethroid resistantAnophelesonly bind DBH-M very weakly, this compound is unlikely to be subject to cross-resistance in a field-based setting. Manipulation of this hormonal signalling pathway therefore represents a potential complementary approach to current malaria control strategies, particularly in areas where high levels of insecticide resistance are compromising existing tools.
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影响因子：
2.8
作者：
Ishtiaq, M.;Salem, Mushtaq A.;Razaq, M.
通讯作者：
Razaq, M.
影响因子：
1.9
作者：
Hunt, RH;Brooke, BD;Coetzee, M
通讯作者：
Coetzee, M
羟基芬芬被An中的P450代谢。冈比亚。
影响因子：
3.8
作者：
Yunta C;Grisales N;Nász S;Hemmings K;Pignatelli P;Voice M;Ranson H;Paine MJ
通讯作者：
Paine MJ
影响因子：
11.8
作者：
Toé KH;Jones CM;N'Fale S;Ismail HM;Dabiré RK;Ranson H
通讯作者：
Ranson H
影响因子：
--
作者：
Lees, Rosemary;Praulins, Giorgio;Malone, David
通讯作者：
Malone, David