Heritability of the Fibromyalgia Phenotype Varies by Age.
Heritability of the Fibromyalgia Phenotype Varies by Age.
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DOI：
10.1002/art.41171
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发表时间：
2020-05
期刊：
影响因子：
--
通讯作者：
Scott LJ
中科院分区：
文献类型：
--
作者：
Dutta D;Brummett CM;Moser SE;Fritsche LG;Tsodikov A;Lee S;Clauw DJ;Scott LJ
许多研究表明纤维肌痛（FM）有很强的家族性成分。然而，这些研究几乎都局限于“原发性”FM患者，即FM没有任何其他伴随疾病。目前的2011-16诊断FM的标准使用疼痛身体部位的数量和躯体症状的严重程度（FM评分）的组合来构建评分。我们估计了不同性别和年龄组的FM评分的遗传遗传力，以确定具有更大遗传力的个体亚组，这可能有助于未来遗传研究的设计。我们收集了26,749名在密歇根大学接受择期手术的欧洲血统个体的数据（密歇根基因组学研究，MGI）。我们使用全基因组关联研究（GWAS）数据和线性混合模型，按年龄和性别类别估计了FM评分的SNP遗传率。总体而言，FM评分的估计遗传率为13.9%（SE=2.9%）。FM评分遗传率估计值在≤ 50岁的个体中最高（23.5%; SE=7.9%），在>60岁的个体中最低（7.3%; SE=8.1%）。当我们将FM作为病例对照表型进行分析时，这些模式保持不变。即使女性的平均FM分数比男性高出约30%，FM分数的遗传性在性别上也没有显著差异。年轻人似乎有一个更强的遗传成分FM分数比老年人。老年人可能更有可能患有以前被称为“继发性FM”的疾病。无论原因如何，这些结果对未来FM和相关疾病的遗传研究具有重要意义。
Many studies suggest a strong familial component to fibromyalgia (FM). However, these studies have nearly all been confined to individuals with “primary” FM, i.e. FM without any other accompanying disorder. The current 2011–16 criteria for diagnosing FM construct a score using a combination of the number of painful body sites and the severity of somatic symptoms (FM-score). We estimated the genetic heritability of FM-score across sex and age groups to identify subgroups of individuals with greater heritability, which may help in the design of future genetic studies. We collected data on 26,749 individuals of European ancestry undergoing elective surgery at the University of Michigan (Michigan Genomics Initiative study, MGI). We estimated the SNP-based heritability of FM-score by age and sex categories using genome-wide association study (GWAS) data and a linear mixed model. Overall, FM-score had an estimated heritability of 13.9% (SE=2.9%). Estimated FM-score heritability was highest in individuals ≤ 50 years of age (23.5%; SE=7.9%) and lowest in individuals >60 years (7.3%; SE=8.1%). These patterns remained the same when we analyzed FM as a case-control phenotype. Even through women had approximately 30% higher average FM-score than males across age categories, FM-score heritability did not differ significantly by sex. Younger individuals appear to have a much stronger genetic component to the FM-score than older individuals. Older individuals may be more likely to have what previously had been called “secondary FM.” Regardless of the cause, these results have implications for future genetic studies of FM and associated conditions.
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影响因子：
30.8
作者：
Dahl A;Iotchkova V;Baud A;Johansson Å;Gyllensten U;Soranzo N;Mott R;Kranis A;Marchini J
通讯作者：
Marchini J
影响因子：
30.8
作者：
Bulik-Sullivan, Brendan K.;Loh, Po-Ru;Finucane, Hilary K.;Ripke, Stephan;Yang, Jian;Patterson, Nick;Daly, Mark J.;Price, Alkes L.;Neale, Benjamin M.
通讯作者：
Neale, Benjamin M.
影响因子：
4
作者：
Lee, Young Ho;Choi, Sung Jae;Song, Gwan Gyu
通讯作者：
Song, Gwan Gyu
DOI：
10.1016/j.berh.2015.04.018
发表时间：
2015-02-01
影响因子：
5.2
作者：
Ablin, Jacob N.;Buskila, Dan
通讯作者：
Buskila, Dan
影响因子：
5.9
作者：
HUDSON, JI;GOLDENBERG, DL;SCHLESINGER, L
通讯作者：
SCHLESINGER, L