Bacillus anthracis lethal toxin induces complex changes in sympathetic nerve discharge regulation.

Bacillus anthracis lethal toxin induces complex changes in sympathetic nerve discharge regulation.
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DOI:
10.1016/j.autneu.2012.06.007
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发表时间:
2012-09-25
影响因子:
2.7
通讯作者:
Fels, R. J.
Fels, R. J.
中科院分区:
医学4区
文献类型:
--
作者:
Kenney, M. J.;Mosher, L. J.;Fels, R. J.

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炭疽杆菌致死毒素(LeTx)改变血压和内脏交感神经放电(SND)调节。目前的结果表明,LeTx输注产生类似的响应曲线在外周(腰椎)和内脏(肾)SND的交感神经流出的初始广泛激活,其次是腰椎和肾脏SND从峰值水平的普遍减少,虽然交感神经抑制往往在腰椎SND衰减。在LeTx输注的膨胀阶段期间,缺氧+高碳酸血症的组合增加了腰椎和肾脏SND,表明交感神经回路可以在B的循环休克阶段期间被激活。炭疽菌败血症
Bacillus anthracis lethal toxin (LeTx) alters blood pressure and visceral sympathetic nerve discharge (SND) regulation. The present results indicate that LeTx infusions produce similar response profiles in peripheral (lumbar) and visceral (renal) SND; an initial widespread activation of sympathetic nerve outflow, followed by a generalized reduction in lumbar and renal SND from peak levels, although the sympathoinhibition tended to be attenuated in lumbar SND. Combined hypoxia+hypercapnia during the hypotensive phase of LeTx infusions increased lumbar and renal SND, indicating that sympathetic neural circuits can be activated during the circulatory shock phase of B. anthracis septicemia.
DOI: 10.1152/ajpregu.1994.267.3.r830
发表时间: 1994-09-01
影响因子: --
作者:
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期刊: JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM
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