Risk factors for de novo and therapy-related myelodysplastic syndromes (MDS).
Risk factors for de novo and therapy-related myelodysplastic syndromes (MDS).
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新发和治疗相关骨髓增生异常综合征（MDS）的风险因素。
DOI：
10.1007/s10552-020-01378-x
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Poynter JN
中科院分区：
文献类型：
--
作者：
Yarosh R;Roesler MA;Murray T;Cioc A;Hirsch B;Nguyen P;Warlick E;Poynter JN
骨髓增生异常综合征（MDS）分为新生和治疗相关（tMDS）。我们分别评估了新发和tmd的MDS危险因素之间的关联。研究人群包括346例新发MDS病例、37例tMDS病例和682例按年龄和性别匹配的人群对照。采用多元逻辑回归计算优势比（OR）和95%置信区间（CI）。调整后，既往吸烟状况（OR=1.45, 95% CI: 1.10-1.93）、个人自身免疫性疾病史（OR= 1.34, 95% CI: 0.99-1.82）和苯暴露（OR=1.48, 95% CI: 1.00-2.19）与新发MDS相关。吸烟、自身免疫性疾病和苯暴露之间的风险估计在程度上相似，但在tMDS病例中不显著。在既往诊断为癌症的个体中，新发MDS病例和对照组更有可能既往有实体瘤，而tMDS病例更常见的是既往有血液恶性肿瘤。我们观察到吸烟、自身免疫性疾病史和苯暴露在新生患者和tMDS之间的类似关联，尽管由于样本量小，对tMDS的估计不精确。未来需要更大样本量的分析来确认环境因素是否影响tMDS的风险。
Myelodysplastic syndromes (MDS) are classified as de novo and therapy-related (tMDS). We evaluated associations between MDS risk factors separately for de novo and tMDS. The study population included 346 de novo MDS cases, 37 tMDS cases and 682 population controls frequency matched by age and sex. Polytomous logistic regression was performed to calculate odds ratios (OR) and 95% confidence intervals (CI). After adjustment, former smoking status (OR=1.45, 95% CI: 1.10-1.93), personal history of autoimmune disease (OR= 1.34, 95% CI: 0.99-1.82) and exposure to benzene (OR=1.48, 95% CI: 1.00-2.19) were associated with de novo MDS. Risk estimates for the associations between smoking, autoimmune disease, and benzene exposure were similar in magnitude but non-significant in tMDS cases. Among individuals with a previous diagnosis of cancer, de novo MDS cases and controls were more likely to have had a previous solid tumor while tMDS cases more commonly had a previous hematologic malignancy. We observed similar associations between smoking, history of autoimmune disease and benzene exposure in de novo and tMDS although estimates for tMDS were imprecise due to small sample sizes. Future analyses with larger sample sizes will be required to confirm whether environmental factors influence risk of tMDS.
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农药暴露作为骨髓增生异常综合征的危险因素：基于 1,942 例病例和 5,359 例对照的荟萃分析。
影响因子：
3.7
作者：
Jin J;Yu M;Hu C;Ye L;Xie L;Jin J;Chen F;Tong H
通讯作者：
Tong H
DOI：
10.1038/nrc.2017.60
发表时间：
2017-08-24
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
McNerney ME;Godley LA;Le Beau MM
通讯作者：
Le Beau MM
影响因子：
5
作者：
Ma, Xiaomei;Lim, Unhee;Schatzkin, Arthur
通讯作者：
Schatzkin, Arthur
影响因子：
3.5
作者：
Montoro, Julia;Gallur, Laura;Valcarcel, David
通讯作者：
Valcarcel, David
影响因子：
3.5
作者：
Pekmezovic, Tatjana;Vukovic, Nada Suvajdzic;Brkic, Nenad
通讯作者：
Brkic, Nenad