Pesticide exposure as a risk factor for myelodysplastic syndromes: a meta-analysis based on 1,942 cases and 5,359 controls.
Pesticide exposure as a risk factor for myelodysplastic syndromes: a meta-analysis based on 1,942 cases and 5,359 controls.
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农药暴露作为骨髓增生异常综合征的危险因素：基于 1,942 例病例和 5,359 例对照的荟萃分析。
DOI：
10.1371/journal.pone.0110850
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Tong H
中科院分区：
文献类型：
--
作者：
Jin J;Yu M;Hu C;Ye L;Xie L;Jin J;Chen F;Tong H
农药暴露与几个部位癌症风险的增加有关，但其与骨髓增生异常综合征(MDS)风险的相关性仍不清楚。对截至2014年4月发表的研究进行了荟萃分析，以调查农药暴露与MDS风险的关系。研究通过搜索科学网、Cochrane图书馆和PubMed数据库来确定。使用随机或固定效应模型计算具有相应95%可信区间(CI)的汇总优势比(OR)。这项荟萃分析包括11项病例对照研究，所有研究均显示农药暴露与MDS风险显著增加相关(OR = 1.95，95%CI 1.23-3.09)。在亚组分析中，如果接触杀虫剂的患者生活在欧洲或亚洲，并患有难治性贫血(RA)或RA合并环状铁粒细胞(RARS)，则他们患MDS的风险增加。此外，在按特定杀虫剂进行的分析中，风险增加与接触杀虫剂有关(OR = 为1.71，95%CI为1.22-2.40)，但与接触除草剂或杀菌剂无关。这一荟萃分析支持了这样一种假设，即接触杀虫剂会增加患MDS的风险。有必要进行进一步的前瞻性队列研究，以验证这种关联并指导临床实践预防MDS。
Pesticide exposure has been linked to increased risk of cancer at several sites, but its association with risk of myelodysplastic syndromes (MDS) is still unclear. A meta-analysis of studies published through April, 2014 was performed to investigate the association of pesticide exposure with the risk of MDS. Studies were identified by searching the Web of Science, Cochrane Library and PubMed databases. Summary odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were calculated using random- or fixed-effect models. This meta-analysis included 11 case-control studies, all of which demonstrated a correlation between pesticide exposure and a statistically significant increased risk of MDS (OR = 1.95, 95% CI 1.23–3.09). In subgroup analyses, patients with pesticide exposure had increased risk of developing MDS if they were living in the Europe or Asia and had refractory anemia (RA) or RA with ringed sideroblasts (RARS). Moreover, in the analysis by specific pesticides, increased risk was associated with exposure to insecticides (OR = 1.71, 95% CI 1.22–2.40) but not exposure to herbicides or fungicides. This meta-analysis supports the hypothesis that exposure to pesticides increases the risk of developing MDS. Further prospective cohort studies are warranted to verify the association and guide clinical practice in MDS prevention.
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DOI：
10.1016/j.jsbmb.2011.08.007
发表时间：
2011-11
影响因子：
4.1
作者：
Schug, Thaddeus T.;Janesick, Amanda;Blumberg, Bruce;Heindel, Jerrold J.
通讯作者：
Heindel, Jerrold J.
影响因子：
6.5
作者：
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通讯作者：
Castoldi, G
影响因子：
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作者：
Hu, Zheng-Hui;Lin, Yi-Wei;Xie, Li-Ping
通讯作者：
Xie, Li-Ping
影响因子：
3.5
作者：
Pekmezovic, Tatjana;Vukovic, Nada Suvajdzic;Brkic, Nenad
通讯作者：
Brkic, Nenad
影响因子：
12.8
作者：
Lv, Ling;Lin, Guowei;Bao, Liming
通讯作者：
Bao, Liming