Exploratory Full-Field Mechanical Analysis across the Osteochondral Tissue-Biomaterial Interface in an Ovine Model.
Exploratory Full-Field Mechanical Analysis across the Osteochondral Tissue-Biomaterial Interface in an Ovine Model.
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DOI：
10.3390/ma13183911
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发表时间：
2020-09-04
期刊：
影响因子：
--
通讯作者：
Jeffers JRT
中科院分区：
文献类型：
--
作者：
Clark JN;Heyraud A;Tavana S;Al-Jabri T;Tallia F;Clark B;Blunn GW;Cobb JP;Hansen U;Jones JR;Jeffers JRT
骨软骨损伤日益普遍，但关节软骨再生的成功仍然难以取得，这就需要开发新的手术干预措施和新的医疗设备。作为设备开发的一部分，动物模型是阐明新型植入物功能的重要里程碑。对组织-生物材料系统的检测对于了解和预测载荷分担能力、固定力学和微运动至关重要，而这些都不是传统的尸检技术直接捕获的。本研究旨在利用实验室微计算机断层扫描、原位加载和数字体积对比的方法，对体外提取的绵羊骨软骨组织-生物材料系统的局部力学性能进行表征。在这里，全场位移和应变分布被可视化跨越系统组件的界面，包括新形成的组织。这项探索性研究的结果表明，植入物相对于周围组织的微运动可以通过多个加载步骤在3D中可视化。该方法提供了一种非破坏性的方法来全面评估设备的性能，为设备设计提供信息以改进骨软骨再生策略。
Osteochondral injuries are increasingly prevalent, yet success in articular cartilage regeneration remains elusive, necessitating the development of new surgical interventions and novel medical devices. As part of device development, animal models are an important milestone in illustrating functionality of novel implants. Inspection of the tissue-biomaterial system is vital to understand and predict load-sharing capacity, fixation mechanics and micromotion, none of which are directly captured by traditional post-mortem techniques. This study aims to characterize the localised mechanics of an ex vivo ovine osteochondral tissue–biomaterial system extracted following six weeks in vivo testing, utilising laboratory micro-computed tomography, in situ loading and digital volume correlation. Herein, the full-field displacement and strain distributions were visualised across the interface of the system components, including newly formed tissue. The results from this exploratory study suggest that implant micromotion in respect to the surrounding tissue could be visualised in 3D across multiple loading steps. The methodology provides a non-destructive means to assess device performance holistically, informing device design to improve osteochondral regeneration strategies.
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影响因子：
3.4
作者：
Fernandez, Marta Pena;Black, Cameron;Tozzi, Gianluca
通讯作者：
Tozzi, Gianluca
影响因子：
41.2
作者：
Darnell, Max;Mooney, David J.
通讯作者：
Mooney, David J.
影响因子：
4.1
作者：
Huang, Brian J.;Brown, Wendy E.;Athanasiou, Kyriacos A.
通讯作者：
Athanasiou, Kyriacos A.
DOI：
10.1177/0309324717748097
发表时间：
2018-02-01
影响因子：
1.6
作者：
Buljac, Ante;Taillandier-Thomas, Thibault;Hild, Francois
通讯作者：
Hild, Francois
影响因子：
3.7
作者：
Balint R;Lowe T;Shearer T
通讯作者：
Shearer T