Resurrecting phenotypes from ancient DNA sequences: promises and perspectives
Resurrecting phenotypes from ancient DNA sequences: promises and perspectives
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从古代 DNA 序列中复活表型：承诺和前景
DOI：
10.1139/cjz-2014-0337
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发表时间：
2015
影响因子：
1.4
通讯作者：
Campbell K
中科院分区：
文献类型：
--
作者：
Campbell K
已灭绝哺乳动物谱系在进化过程中的解剖学变化，如手指和牙齿的丧失以及伴随着中新世晚期斯特勒海牛祖先的扩散而出现的身体大小的迅速增加（Hydrodamalis gigas（Zimmermann，1780））进入北太平洋沃茨，并在羊毛猛犸象的耳朵和尾巴表面积减少的情况下，（Mammuthus artigius（Blumenbach，1799））和羊毛犀牛（Coelodonta antiquitatis（Blumenbach，1799））是开发新栖息地的适应性进化的主要例子。然而，在这些进化转变过程中采用的生物化学特化很可能具有相似或甚至更大的生物学重要性。由于这些“活的”过程并不复杂，关于灭绝物种生理特征的直接信息在很大程度上仍然超出了科学研究的范围。然而，从古代DNA样本中检索基因组序列的能力，结合异位表达系统，现在允许非常详细地研究真正的史前蛋白质的进化起源和结构和功能特性。在古代DNA检索、富集和测序方面的指数级技术进步将很快允许从过去一百万年的数百个灭绝物种中有针对性地产生完整的基因组，与新兴的体外表达、基因组工程和细胞分化技术相结合，有望预示着生物化学、基因组学、古生物学、和细胞生物学。
Anatomical changes in extinct mammalian lineages over evolutionary time, such as the loss of fingers and teeth and the rapid increase in body size that accompanied the late Miocene dispersal of the progenitors of Steller’s sea cows (Hydrodamalis gigas(Zimmermann, 1780)) into North Pacific waters and the convergent development of a thick pelage and accompanying reductions in ear and tail surface area of woolly mammoths (Mammuthus primigenius(Blumenbach, 1799)) and woolly rhinoceros (Coelodonta antiquitatis(Blumenbach, 1799)), are prime examples of adaptive evolution underlying the exploitation of new habitats. It is likely, however, that biochemical specializations adopted during these evolutionary transitions were of similar or even greater biological importance. As these “living” processes do not fossilize, direct information regarding the physiological attributes of extinct species has largely remained beyond the range of scientific inquiry. However, the ability to retrieve genomic sequences from ancient DNA samples, combined with ectopic expression systems, now permit the evolutionary origins and structural and functional properties of authentic prehistoric proteins to be examined in great detail. Exponential technical advances in ancient DNA retrieval, enrichment, and sequencing will soon permit targeted generation of complete genomes from hundreds of extinct species across the last one million years that, in combination with emerging in vitro expression, genome engineering, and cell differentiation techniques, promises to herald an exciting new trajectory of evolutionary research at the interface of biochemistry, genomics, palaeontology, and cell biology.
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DOI：
10.1126/science.1224344
发表时间：
2012-10-12
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Meyer M;Kircher M;Gansauge MT;Li H;Racimo F;Mallick S;Schraiber JG;Jay F;Prüfer K;de Filippo C;Sudmant PH;Alkan C;Fu Q;Do R;Rohland N;Tandon A;Siebauer M;Green RE;Bryc K;Briggs AW;Stenzel U;Dabney J;Shendure J;Kitzman J;Hammer MF;Shunkov MV;Derevianko AP;Patterson N;Andrés AM;Eichler EE;Slatkin M;Reich D;Kelso J;Pääbo S
通讯作者：
Pääbo S
影响因子：
17.3
作者：
Gaj, Thomas;Gersbach, Charles A.;Barbas, Carlos F., III
通讯作者：
Barbas, Carlos F., III
DOI：
10.1016/j.palaeo.2014.06.026
发表时间：
2014-12-15
影响因子：
3
作者：
Buckley, M.;Wadsworth, C.
通讯作者：
Wadsworth, C.
巨型动物分叉：已灭绝猛犸象和披毛犀毛发结构和功能的微观表征
影响因子：
4
作者：
S. Tridico;P. Rigby;K. Kirkbride;J. Haile;M. Bunce
通讯作者：
M. Bunce
影响因子：
64.8
作者：
通讯作者：
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