A stochastic model for early placental development.
A stochastic model for early placental development.
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DOI：
10.1098/rsif.2014.0149
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发表时间：
2014-08-06
期刊：
影响因子：
--
通讯作者：
Heazell AE
中科院分区：
文献类型：
--
作者：
Cotter SL;Klika V;Kimpton L;Collins S;Heazell AE
在人类中，胎盘结构与胎盘功能和妊娠结局密切相关。研究指出，胎龄小的婴儿胎盘形状异常会增加其一生患心血管疾病的风险。胎盘形状的起源和决定因素尚不完全清楚，很难在体内进行研究。在本文中，我们模拟了人类胎盘的早期发育，基于这是由蜕膜近端螺旋动脉发出的化学引诱剂效应驱动的假设。我们推导并探索了一个二维随机模型，并研究了脐带插入附近螺旋动脉丢失对胎盘形状的影响。该模型表明，螺旋动脉的破坏可以对胎盘形状产生深远的影响，特别是如果这是靠近脐带插入。因此，胎盘的形状反映了母体下伏的血管床。异常的胎盘形状可能反映了异常的子宫环境，易导致妊娠并发症。通过对模型胎盘的统计分析，我们能够描述给定胎盘在中断环境中生长的概率，甚至能够区分不同的中断。
In the human, placental structure is closely related to placental function and consequent pregnancy outcome. Studies have noted abnormal placental shape in small-for-gestational-age infants which extends to increased lifetime risk of cardiovascular disease. The origins and determinants of placental shape are incompletely understood and are difficult to study in vivo. In this paper, we model the early development of the human placenta, based on the hypothesis that this is driven by a chemoattractant effect emanating from proximal spiral arteries in the decidua. We derive and explore a two-dimensional stochastic model, and investigate the effects of loss of spiral arteries in regions near to the cord insertion on the shape of the placenta. This model demonstrates that disruption of spiral arteries can exert profound effects on placental shape, particularly if this is close to the cord insertion. Thus, placental shape reflects the underlying maternal vascular bed. Abnormal placental shape may reflect an abnormal uterine environment, predisposing to pregnancy complications. Through statistical analysis of model placentas, we are able to characterize the probability that a given placenta grew in a disrupted environment, and even able to distinguish between different disruptions.
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