Amorphous silica fiber matrix biomaterials: An analysis of material synthesis and characterization for tissue engineering.
Amorphous silica fiber matrix biomaterials: An analysis of material synthesis and characterization for tissue engineering.
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DOI：
10.1016/j.bioactmat.2022.04.002
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发表时间：
2023-01
影响因子：
18.9
通讯作者：
Nukavarapu, Syam P.
中科院分区：
文献类型：
--
作者：
Kim, Hyun S.;Kumbar, Sangamesh G.;Nukavarapu, Syam P.
包括生物玻璃在内的二氧化硅生物材料具有良好的生物相容性和生物活性，但无法提供组织工程所需的孔隙和降解特征。本文报道了一种新型非晶硅纤维基质的合成和表征，以克服这些限制。采用烧结法制备了非晶态二氧化硅纤维。研究了牺牲聚合物添加剂聚乙烯醇（PVA）和纤维素纤维（CF）对烧结过程的影响。在1350 - 1550°C的烧结温度下形成的最终基体保留了其纤维结构。烧结温度越高，孔径越大，孔径大小在50 ~ 200 μm之间。与添加或未添加CF的二氧化硅基体相比，添加PVA的二氧化硅基体的孔径和孔隙率显著降低。在形态学上，PVA添加剂对二氧化硅纤维的融合程度更大，其抗压模量和强度明显高于其他合成的基体。在40周的体外降解研究中，这些基质失去了大约30%的原始质量。所有基质都吸收了500wt %的水，并且在水合作用下它们的整体形态、大小或形状都没有改变。这些纤维基质支持人间充质干细胞的粘附、增殖和矿化基质的产生。本文报道的无定形二氧化硅纤维生物材料/基质具有可生物降解和多孔性，与天然细胞外基质结构和吸水能力非常相似。将本文报道的方法扩展到改变基质特性可能会导致各种组织工程，植入物和药物输送应用。无定形二氧化硅生物材料和结构。具有纤维状结构、吸水、生物降解、细胞相容性、易于加工和灭菌等独特特性的无定形二氧化硅多孔接枝合成：一种用于组织工程的新型生物材料平台。
Silica biomaterials including Bioglass offer great biocompatibility and bioactivity but fail to provide pore and degradation features needed for tissue engineering. Herein we report on the synthesis and characterization of novel amorphous silica fiber matrices to overcome these limitations. Amorphous silica fibers were fused by sintering to produce porous matrices. The effects of sacrificial polymer additives such as polyvinyl alcohol (PVA) and cellulose fibers (CF) on the sintering process were also studied. The resulting matrices formed between sintering temperatures of 1,350–1,550 °C retained their fiber structures. The matrices presented pores in the range of 50–200 μm while higher sintering temperatures resulted in increased pore diameter. PVA addition to silica significantly reduced the pore diameter and porosity compared with silica matrices with or without the addition of CF. The PVA additive morphologically appeared to fuse the silica fibers to a greater extent and resulted in significantly higher compressive modulus and strength than the rest of the matrices synthesized. These matrices lost roughly 30% of their original mass in an in vitro degradation study over 40 weeks. All matrices absorbed 500 wt% of water and did not change in their overall morphology, size, or shape with hydration. These fiber matrices supported human mesenchymal stem cell adhesion, proliferation, and mineralized matrix production. Amorphous silica fiber biomaterials/matrices reported here are biodegradable and porous and closely resemble the native extracellular matrix structure and water absorption capacity. Extending the methodology reported here to alter matrix properties may lead to a variety of tissue engineering, implant, and drug delivery applications. Amorphous silica biomaterials and structures. Amorphous silica porous graft synthesis with unique features - fibrillar structure, water absorption, biodegradation, cell compatibility, ease of processing, and sterilization: A novel biomaterial platform for tissue engineering.
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影响因子：
18.9
作者：
Barbeck M;Serra T;Booms P;Stojanovic S;Najman S;Engel E;Sader R;Kirkpatrick CJ;Navarro M;Ghanaati S
通讯作者：
Ghanaati S
影响因子：
3.8
作者：
Amini, A. R.;Nukavarapu, S. P.
通讯作者：
Nukavarapu, S. P.
影响因子：
3.5
作者：
ANDERSSON, OH;KARLSSON, KH;KANGASNIEMI, K
通讯作者：
KANGASNIEMI, K
DOI：
10.1002/jbm.820080307
发表时间：
1974-01-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
HENCH, LL;PASCHALL, HA
通讯作者：
PASCHALL, HA
影响因子：
6.4
作者：
Annabi, Nasim;Nichol, Jason W.;Dehghani, Fariba
通讯作者：
Dehghani, Fariba