TLR7 Activation Accelerates Cardiovascular Pathology in a Mouse Model of Lupus.
TLR7 Activation Accelerates Cardiovascular Pathology in a Mouse Model of Lupus.
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DOI：
10.3389/fimmu.2022.914468
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发表时间：
2022
影响因子：
7.3
通讯作者：
Morel L
中科院分区：
文献类型：
--
作者：
Elshikha AS;Teng XY;Kanda N;Li W;Choi SC;Abboud G;Terrell M;Fredenburg K;Morel L
我们报道了TLR7激动剂R848在狼疮易发B6.Sle1.Sle2中加速狼疮相关心血管病理的新模型。Sle3 （TC）小鼠。r848治疗的TC小鼠，而非自身免疫性C57BL/6 （B6）对照小鼠，出现微血管炎症和细胞内空泡化的肌细胞溶解。这种组织病理学类似于心脏移植后抗体介导的排斥反应，尽管它不涉及补体。接受r848处理的TC小鼠血清或脾细胞的TC或B6受体出现反应性心肌细胞肥大，这在老年TC小鼠和TC中也自发出现。缺少B细胞和T细胞的Rag-/-小鼠。这些心血管病变中的每一种都与狼疮患者报告的异常相对应。淋巴和非淋巴免疫细胞以及可溶性因子有助于TC小鼠狼疮相关心血管病变，现在可以使用该模型进行解剖，无论是否使用R848治疗。
We report a novel model of lupus-associated cardiovascular pathology accelerated by the TLR7 agonist R848 in lupus-prone B6.Sle1.Sle2.Sle3 (TC) mice. R848-treated TC mice but not non-autoimmune C57BL/6 (B6) controls developed microvascular inflammation and myocytolysis with intracellular vacuolization. This histopathology was similar to antibody-mediated rejection after heart transplant, although it did not involve complement. The TC or B6 recipients of serum or splenocytes from R848-treated TC mice developed a reactive cardiomyocyte hypertrophy, which also presents spontaneously in old TC mice as well as in TC.Rag-/- mice that lack B and T cells. Each of these cardiovascular lesions correspond to abnormalities that have been reported in lupus patients. Lymphoid and non-lymphoid immune cells as well as soluble factors contribute to lupus-associated cardiovascular lesions in TC mice, which can now be dissected using this model with and without R848 treatment.
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DOI：
10.4049/jimmunol.1202195
发表时间：
2012-12-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Hwang SH;Lee H;Yamamoto M;Jones LA;Dayalan J;Hopkins R;Zhou XJ;Yarovinsky F;Connolly JE;Curotto de Lafaille MA;Wakeland EK;Fairhurst AM
通讯作者：
Fairhurst AM
影响因子：
32.4
作者：
Berland, Robert;Fernandez, Luis;Imanishi-Kari, Thereza
通讯作者：
Imanishi-Kari, Thereza
影响因子：
2.7
作者：
Fishbein, Gregory A.;Fishbein, Michael C.
通讯作者：
Fishbein, Michael C.
影响因子：
2.6
作者：
Doria, A;Iaccarino, L;Petri, M
通讯作者：
Petri, M
影响因子：
37.8
作者：
KARAM, R;HEALY, BP;WICKER, P
通讯作者：
WICKER, P