A longitudinal study of the corpus callosum in chronic schizophrenia.
A longitudinal study of the corpus callosum in chronic schizophrenia.
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DOI：
10.1016/j.schres.2009.07.021
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发表时间：
2009-10
影响因子：
4.5
通讯作者：
Buchsbaum, Monte S.
中科院分区：
文献类型：
--
作者：
Mitelman, Serge A.;Nikiforova, Yekaterina K.;Canfield, Emily L.;Hazlett, Erin A.;Brickman, Adam M.;Shihabuddin, Lina;Buchsbaum, Monte S.
胼胝体大小减小和各向异性在精神分裂症患者中已被描述，但其纵向进展仍知之甚少。我们对49名慢性精神分裂症患者和16名健康对照者在基线和4年后的随访中进行了弥散张量和结构磁共振成像。精神分裂症患者又分为预后良好组（n=23）和预后不良组（n=26）。评估基线至随访期间胼胝体的大小、形状、位置和分数各向异性的变化，胼胝体分为5个矢状段和5个头尾段。在基线扫描和与健康受试者相比，精神分裂症患者表现出1)胼胝体尺寸较小，2)除中线外所有矢状面各向异性平均值较低，3)背侧平均坐标位置较高。在基线扫描后的四年里，精神分裂症患者的胼胝体的绝对大小比健康对照者表现出更明显的下降。与预后良好组相比，预后较差患者的胼胝体在基线时尺寸更小，平均各向异性更低，更长，位置更后。在随访期间，与预后良好的患者相比，预后差的患者表现出更明显的胼胝体大小下降，但胼胝体各向异性下降不那么明显。精神分裂症患者和健康受试者在基线时胼胝体大小的差异在疾病的慢性期继续扩大，特别是在功能预后差的患者中。然而，不同结果的患者胼胝体各向异性的基线差异随着时间的推移而减少。
Decreased callosal size and anisotropy have been described in schizophrenia patients but their longitudinal progression remains poorly understood. We performed diffusion-tensor and structural magnetic resonance imaging at baseline and at follow-up four years later in 49 chronic schizophrenia patients and 16 healthy comparison subjects. Schizophrenia patients were subdivided into good-outcome (n=23) and poor-outcome (n=26) groups. Baseline-to-follow-up changes in size, shape, position and fractional anisotropy of the corpus callosum, divided into five sagittal sections and five rostro-caudal segments, were assessed. At baseline scan and in comparison to healthy subjects, schizophrenia patients displayed 1) smaller callosal size, 2) lower average anisotropy in all sagittal sections except the midline, 3) more dorsal average coordinate position. During the four years after the baseline scan, patients with schizophrenia exhibited a more pronounced decline in absolute size of the corpus callosum than healthy comparison subjects. As compared with the good-outcome group, the corpus callosum in poor-outcome patients at baseline was of smaller size and lower average anisotropy, more elongated and posteriorly positioned. During the follow-up interval, poor-outcome patients displayed a more pronounced decline in size but less pronounced decline in anisotropy of the corpus callosum than patients with good outcomes. Differences in callosal size between schizophrenia patients and healthy subjects seen at baseline continue to widen in the chronic phase of the illness, especially in patients with poor functional outcome. Baseline differences in callosal anisotropy among patients with different outcomes, however, diminish over time.
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影响因子：
1.7
作者：
Carpenter DM;Tang CY;Friedman JI;Hof PR;Stewart DG;Buchsbaum MS;Harvey PD;Gorman JG;Davis KL
通讯作者：
Davis KL
影响因子：
1.7
作者：
Agartz, I;Andersson, JLR;Skare, S
通讯作者：
Skare, S
影响因子：
11
作者：
Foong, J;Maier, M;Ron, MA
通讯作者：
Ron, MA
影响因子：
4.5
作者：
Goghari, VM;Lang, DJ;Honer, WG
通讯作者：
Honer, WG
影响因子：
6.9
作者：
Cheung, V.;Cheung, C.;Chua, S. E.
通讯作者：
Chua, S. E.