Cerebellar abnormalities following hypoxia alone compared to hypoxic-ischemic forebrain injury in the developing rat brain.
Cerebellar abnormalities following hypoxia alone compared to hypoxic-ischemic forebrain injury in the developing rat brain.
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DOI：
10.1016/j.nbd.2010.09.001
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发表时间：
2011-01
影响因子：
6.1
通讯作者：
Ferriero, Donna M.
中科院分区：
文献类型：
--
作者：
Biran, Valerie;Heine, Vivi M.;Verney, Catherine;Sheldon, R. Ann;Spadafora, Ruggero;Vexler, Zinaida S.;Rowitch, David H.;Ferriero, Donna M.
2天大（P2）的大鼠幼仔进行全身缺氧或右颈动脉电凝，然后进行2.5小时的缺氧。用免疫组织学方法观察小鼠第1、2、19天小脑细胞和局部损伤情况。在缺氧和缺氧缺血后，一部分浦肯野细胞的CB所有神经元群均受损。缺氧后，中间神经元数量、分子层和颗粒层厚度均明显减少。缺氧后弥漫性白质损伤伴少突胶质细胞丢失比缺氧缺血更严重。P2大鼠的整体缺氧对脑后皮层不同区域的许多细胞类型产生广泛的损伤。单侧前脑缺血的增加不会增加这些变化的严重程度。我们的数据提供了洞察机制的变化，观察到早产儿的CB。
Two-day-old (P2) rat pups were subjected to either a global hypoxia or to electrocoagulation of the right carotid artery followed by 2.5 hrs hypoxia. Cellular and regional injury in the cerebellum (CB) was studied at 1, 2 and 19 days using immunohistology. Following hypoxia and hypoxia-ischemia, all neuronal populations of the CB were damaged in a subset of Purkinje cells. The decrease in the number of interneurons, as well as the thickness of molecular and granular layers was significant following hypoxia. Diffuse white matter damage, with loss of preoligodendrocytes was more severe following hypoxia than hypoxia-ischemia. Global hypoxia in the rat at P2 produces extensive damage to many cell types in different areas of the CB. The addition of unilateral forebrain ischemia does not increase the severity of these changes. Our data provide insight into the mechanisms of the changes observed in the CB of premature newborns.
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影响因子：
1.9
作者：
Bodensteiner, JB;Johnsen, SD
通讯作者：
Johnsen, SD
影响因子：
3.6
作者：
Messerschmidt, Agnes;Fuiko, Renate;Birnbacher, Robert
通讯作者：
Birnbacher, Robert
DOI：
10.1016/j.devbrainres.2005.02.002
发表时间：
2005-04-21
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
Peng, JHF;Feng, YZ;Parker, JC
通讯作者：
Parker, JC
影响因子：
2.5
作者：
BRODAL, P;BRODAL, A
通讯作者：
BRODAL, A
影响因子：
14.5
作者：
Nosarti, Chiara;Giouroukou, Elena;Murray, Robin M.
通讯作者：
Murray, Robin M.