Offspring birthweight by gestational age and parental cardiovascular mortality: a population-based cohort study.
Offspring birthweight by gestational age and parental cardiovascular mortality: a population-based cohort study.
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DOI：
10.1111/1471-0528.14522
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Skjaerven R
中科院分区：
文献类型：
--
作者：
Morken NH;Halland F;DeRoo LA;Wilcox AJ;Skjaerven R
通过子代出生体重估计父母心血管疾病死亡风险。基于人群的队列研究。1967-2002年期间，通过与挪威死因登记处的联系，对挪威单胎生育的母亲和父亲进行了跟踪调查，直到2009年。使用Cox回归计算后代绝对出生体重（g）和校正胎龄（z评分）的出生体重的风险比（HR），并校正分娩时的父母年龄和首次分娩年份。对早产和足月分娩进行了分层分析。母亲和父亲的心血管死亡率。我们跟踪了711726名母亲和700212名父亲，发现母亲心血管死亡率和后代出生体重之间存在密切联系，但只有轻微的证据表明父亲之间存在关联。根据胎龄调整出生体重（通过z评分）发现，出生体重过大（z评分>2.5）与母亲心血管死亡率之间存在意想不到的强相关性（HR：3.0，95% CI：2.0-4.6）。这种风险显然仅限于早产。在分层分析（早产和足月分娩）中，分别使用正常体重早产儿和足月儿作为参考，大型早产儿和大型足月儿的母体心血管死亡率HR分别为1.5（1.03-2.2）和0.9（0.7-1.2）（相互作用的p值= 0.02）。有大早产儿的妇女患糖尿病和心血管死亡的风险增加。大早产儿的出生应提高临床对糖尿病和其他心血管疾病危险因素的警惕。
To estimate risk of parental cardiovascular disease mortality by offspring birth weight. Population-based cohort study. Norwegian mothers and fathers with singleton births during 1967–2002 were followed until 2009 by linkage to the Norwegian cause of death registry. Hazard ratios (HR) by offspring absolute birth weight in gram and birthweight adjusted for gestational age (z-score) were calculated using Cox-regression and adjusted for parental age at delivery and year of first birth. Stratified analyses on preterm and term births were performed. Maternal and paternal cardiovascular mortality. We followed 711 726 mothers and 700 212 fathers and found a strong link between maternal cardiovascular mortality and offspring birth weight but only slight evidence of associations in fathers. Adjusting birth weight for gestational age (by z-score) uncovered an unexpected strong association of large birth weight (z-score >2.5) with mothers cardiovascular mortality (HR: 3.0, 95% CI: 2.0–4.6). This risk was apparently restricted to preterm births. In stratified analyses (preterm and term births) HR for maternal cardiovascular mortality was 1.5 (1.03–2.2) for large preterm babies and 0.9 (0.7–1.2) for large term babies (p-value for interaction = 0.02), using normal weight preterm and term, respectively as references. Women having large preterm babies are at increased risk of both diabetes and cardiovascular mortality. The birth of a large preterm baby should increase clinical vigilance for onset of diabetes and other cardiovascular-disease risk factors.
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影响因子：
7.2
作者：
Halland F;Morken NH;DeRoo LA;Klungsøyr K;Wilcox AJ;Skjærven R
通讯作者：
Skjærven R
影响因子：
6.7
作者：
Christian, Lisa M.
通讯作者：
Christian, Lisa M.
影响因子：
6.3
作者：
Lawlor, DA;Smith, GD;Ebrahim, S
通讯作者：
Ebrahim, S
影响因子：
5.6
作者：
Friedlander, Yechiel;Paltiel, Ora;Harlap, Susan
通讯作者：
Harlap, Susan
影响因子：
--
作者：
Smith, GD;Harding, S;Rosato, M
通讯作者：
Rosato, M