Environmental novelty elicits a later theta phase of firing in CA1 but not subiculum.
Environmental novelty elicits a later theta phase of firing in CA1 but not subiculum.
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DOI：
10.1002/hipo.20671
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发表时间：
2010-02
期刊：
影响因子：
3.5
通讯作者：
O'Keefe, John
中科院分区：
文献类型：
--
作者：
Lever, Colin;Burton, Stephen;Jeewajee, Ali;Wills, Thomas J.;Cacucci, Francesca;Burgess, Neil;O'Keefe, John
支持海马体形成在新颖性检测中的作用的机制仍然存在争议。比较器功能被认为是CA1或耻骨下的功能，而θ节律被认为是将神经放电分为编码和检索阶段。我们研究了大鼠在熟悉和陌生环境中觅食时，枕下和CA1主要细胞的θ期放电。我们发现，在环境新奇时，CA1的首选θ波相位，而不是枕下，被转移到θ波周期的较晚阶段。此外，环境变化引起的相移量与CA1中位置细胞重映射的程度相关。我们的研究结果支持θ相位与CA1中新颖性诱导的可塑性之间的关系。
The mechanism supporting the role of the hippocampal formation in novelty detection remains controversial. A comparator function has been variously ascribed to CA1 or subiculum, while the theta rhythm has been suggested to separate neural firing into encoding and retrieval phases. We investigated theta phase of firing in principal cells in subiculum and CA1 as rats foraged in familiar and novel environments. We found that the preferred theta phase of firing in CA1, but not subiculum, was shifted to a later phase of the theta cycle during environmental novelty. Furthermore, the amount of phase shift elicited by environmental change correlated with the extent of place cell remapping in CA1. Our results support a relationship between theta phase and novelty-induced plasticity in CA1.
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theta修饰的大鼠海马形成中的划分细胞。
DOI：
10.1523/jneurosci.2635-04.2004
发表时间：
2004-09-22
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cacucci F;Lever C;Wills TJ;Burgess N;O'Keefe J
通讯作者：
O'Keefe J
影响因子：
2.9
作者：
Hasselmo, ME;Bodelón, C;Wyble, BP
通讯作者：
Wyble, BP
影响因子：
56.9
作者：
Leutgeb, S;Letugeb, JK;Moser, MB
通讯作者：
Moser, MB
影响因子：
2.7
作者：
Manns, Joseph R.;Zilli, Eric A.;Eichenbaum, Howard
通讯作者：
Eichenbaum, Howard
影响因子：
5.3
作者：
Csicsvari, J;Hirase, H;Buzsáki, G
通讯作者：
Buzsáki, G