Epidermal T cells: their functional role and disease relevance for dermatologists.
Epidermal T cells: their functional role and disease relevance for dermatologists.
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表皮 T 细胞：其功能作用和与皮肤科医生的疾病相关性。
DOI：
--
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发表时间：
1997
影响因子：
6.5
通讯作者：
Noriko Moriya
中科院分区：
文献类型：
--
作者：
T. Shiohara;Noriko Moriya
在炎症性皮肤病的表皮中发现的T细胞被普遍认为是造成表皮损伤的主要原因。另一方面，驻留在小鼠表皮中的T细胞被认为在保护表皮免受潜在危险的免疫反应中发挥着重要作用。大量证据表明，表达单态TCR Gammadelta的树突状表皮T细胞(DETC)负责保护表皮结构免受皮肤肿瘤、细菌感染和自身免疫攻击。在先天缺乏这些Gammadelta+DETC的动物中，表皮上充斥着骨髓来源的TCR Alphabeta+，CD8+DETC。尽管目前尚不清楚DETC的这一亚群是否存在于表皮以替代Gammadelta+DETC的生理功能，或者它们是否与表皮损伤有关，但应该注意的是，这一亚群代表了存在于正常人表皮中的主要T细胞，并在固定性药疹(FDE)的皮损表皮中含量最高。由于它们在刺激时能够杀死包括角质形成细胞在内的靶细胞，并且利用的TCRVα和Vbeta基因家族范围非常有限，因此FDE皮损中的局限性表皮损伤将通过激活这些具有自侵袭潜力的表皮T细胞来介导。因此，表皮T细胞很可能形成几个具有不同免疫功能的T细胞群，这些T细胞群由不同的刺激模式触发。表皮的免疫动态平衡依赖于至少两种类型的表皮T细胞之间的微妙平衡：自攻性T细胞和保护性T细胞。
T cells found within the epidermis in inflammatory dermatoses are generally accepted as making a major contribution to epidermal damage. On the other hand, those T cells residing in the murine epidermis are supposed to play an important role in protecting the epidermis from potentially dangerous immune reactions. Overwhelming evidence has accumulated that dendritic epidermal T cells (DETC) expressing monomorphic TCR gammadelta are responsible for the protection of epidermal structures against skin tumor, bacterial infection, and autoimmune attack. In animals congenitally lacking these gammadelta+ DETC, the epidermis is populated with bone marrow-derived TCR alphabeta+, CD8+ DETC. Although it remains unclear whether this subset of DETC could home to the epidermis to substitute for the physiologic function of gammadelta+ DETC or whether they would be pathologically relevant to epidermal injury, it should be noted that this subset represents the major fraction of T cells present in normal human epidermis and the most abundant in the lesional epidermis of fixed drug eruption (FDE). Because they are shown to kill target cells including keratinocytes upon stimulation and utilize a very limited range of TCR V alpha and Vbeta gene families, localized epidermal injury in FDE lesions would be mediated by activation of these epidermal T cells with autoaggressive potential. Epidermal T cells are thus likely to form several T-cell populations with different immunologic functions that are triggered by different modes of stimulation. Immune homeostasis in the epidermis would rely on a delicate balance between at least two types of epidermal T cells: autoaggressive T cells and protective T cells.
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DOI：
10.1038/jid.1983.4
发表时间：
1983-06
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
J. Streilein
通讯作者：
J. Streilein
正常人表皮中的 T 细胞亚群。
DOI：
--
发表时间：
1996
期刊：
The American journal of pathology
影响因子：
--
作者：
Spetz,AL;Strominger,J;Groh-Spies,V
通讯作者：
Groh-Spies,V
影响因子：
56.9
作者：
HAVRAN, WL;CHIEN, YH;ALLISON, JP
通讯作者：
ALLISON, JP
影响因子：
56.9
作者：
BOISMENU, R;HAVRAN, WL
通讯作者：
HAVRAN, WL
整合素 α E β 7 介导 T 淋巴细胞与上皮细胞的粘附。
DOI：
--
发表时间：
1993
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Cepek,KL;Parker,CM;Madara,JL;Brenner,MB
通讯作者：
Brenner,MB