Adolescent binge ethanol treatment alters adult brain regional volumes, cortical extracellular matrix protein and behavioral flexibility.
Adolescent binge ethanol treatment alters adult brain regional volumes, cortical extracellular matrix protein and behavioral flexibility.
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DOI：
10.1016/j.pbb.2013.11.021
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发表时间：
2014-01
影响因子：
3.6
通讯作者：
Crews, Fulton T.
中科院分区：
文献类型：
--
作者：
Coleman, Leon Garland, Jr.;Liu, Wen;Oguz, Ipek;Styner, Martin;Crews, Fulton T.
青少年比其他年龄段的人酗酒更多，这增加了破坏额叶皮层发育的风险。我们假设青少年酗酒会导致成年后的持续改变。在这项研究中，我们使用青春期小鼠（出生后第28-37天[P]）模拟了青春期周末未成年酗酒。青少年间歇性酒精狂欢（AIE）治疗包括在整个青春期以间歇模式进行6次酒精胃内狂欢给药。在成年期延长禁欲后进行评估，以确定成年人是否有持续的变化。使用磁成像和免疫组织化学测定了记忆学习、开放视野和其他行为评估以及脑结构。我们发现AIE并不影响成年巴恩斯的迷宫学习。然而，AIE确实会导致成人的逆转性学习障碍。AIE还引起了成人大脑的结构变化。AIE与成年期特定脑区体积增大相关，而脑总体积无变化。扩大的区域包括眶额皮质（OFC，4%）、小脑（4.5%）、丘脑（2%）、内囊（10%）和胼胝体下丘脑（7%）。成人AIE后OFC体积增大与之前在人类青少年中的成像研究一致。AIE治疗与成人OFC中几种细胞外基质（ECM）蛋白表达的显著增加相关，包括WFA（55%）、Brevican（32%）、Neurocan（105%）、Tenacin-C（25%）和HABP（5%）。这些发现与AIE导致大脑结构的持续变化一致，这可能导致缺乏行为灵活性。
Adolescents binge drink more than any other age group, increasing risk of disrupting the development of the frontal cortex. We hypothesized that adolescent binge drinking would lead to persistent alterations in adulthood. In this study, we modeled adolescent weekend underage binge-drinking, using adolescent mice (post-natal days [P] 28–37). The adolescent intermittent binge ethanol (AIE) treatment includes 6 binge intragastric doses of ethanol in an intermittent pattern across adolescence. Assessments were conducted in adulthood following extended abstinence to determine if there were persistent changes in adults. Reversal learning, open field and other behavioral assessments as well as brain structure using magnetic imaging and immunohistochemistry were determined. We found AIE did not impact adult Barnes Maze learning. However, AIE did cause reversal learning deficits in adults. AIE also caused structural changes in the adult brain. AIE was associated with adulthood volume enlargements in specific brain regions without changes in total brain volume. Enlarged regions included the orbitofrontal cortex (OFC, 4%), cerebellum (4.5%), thalamus (2%), internal capsule (10%) and genu of the corpus callosum (7%). The enlarged OFC volume in adults after AIE is consistent with previous imaging studies in human adolescents. AIE treatment was associated with significant increases in the expression of several extracellular matrix (ECM) proteins in the adult OFC including WFA (55%), Brevican (32%), Neurocan (105%), Tenacin-C (25%), and HABP (5%). These findings are consistent with AIE causing persistent changes in brain structure that could contribute to a lack of behavioral flexibility.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
产后NMDA拮抗剂治疗后，成人前额叶皮层神经元的缺陷和行为。
影响因子：
3.6
作者：
Coleman, Leon G., Jr.;Jarskog, L. Fredrik;Moy, Sheryl S.;Crews, Fulton T.
通讯作者：
Crews, Fulton T.
青少年暴饮暴食改变了小鼠的成人脑神经递质的表达，行为，大脑区域体积和神经化学。
DOI：
10.1111/j.1530-0277.2010.01385.x
发表时间：
2011-04
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Coleman LG Jr;He J;Lee J;Styner M;Crews FT
通讯作者：
Crews FT
影响因子：
8.2
作者：
Gong, Gu;Yuan, Li-bang;Zhou, Le-shun
通讯作者：
Zhou, Le-shun
影响因子：
15.9
作者：
Celio, MR;Spreafico, R;Vitellaro-Zuccarello, L
通讯作者：
Vitellaro-Zuccarello, L