Dispersal process associated with the L1 family of interspersed repetitive DNA sequences.
Dispersal process associated with the L1 family of interspersed repetitive DNA sequences.
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与散布重复 DNA 序列的 L1 家族相关的分散过程。
DOI：
10.1016/0022-2836(84)90312-7
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发表时间：
1984
影响因子：
5.6
通讯作者：
Edgell,MH
中科院分区：
文献类型：
--
作者：
Voliva,CF;Martin,SL;Hutchison3rd,CA;Edgell,MH
我们已经从BALB/c小鼠的β-珠蛋白基因区确定了L1Md重复家族的五个成员的完整核苷酸序列。这五个重复序列是不同长度的，每个在彼此不同的点处终止于5‘端。我们已经分析了五个重复序列末端周围的核苷酸，以寻找与该重复序列家族的扩散和5‘截断有关的机制的线索。每个L1成员的两侧都有一对短的直接重复序列。由于这些直接重复序列在每一种情况下的长度和序列都不同，因此扩散机制不涉及序列靶向过程。3‘端的序列是保守的，其组织类似于多聚腺苷RNA的3’端，这表明重复序列的转录本直接或作为中间产物参与了该序列的互补DNA拷贝的产生。其中一个L1重复序列是最近插入的，因为它存在于Hbbd染色体中，但不存在于Hbbschromosome中。这表明了一种直到400万年前才活跃的扩散过程。
We have determined the complete nucleotide sequence for five members of the L1Md repetitive family from the beta-globin gene region of the BALB/c mouse. The five repeats are different lengths, each terminating at the 5′ end at different points with respect to one another. We have analyzed the nucleotides around the endpoints of the five repeats for clues as to the mechanisms involved with the dispersal and 5′ truncation of this repeat family. Each L1 member is flanked by a pair of short direct repeats. Since these direct repeats differ in length and sequence in each of the five cases, the dispersal mechanism does not involve a sequence targeted process. The sequence at the 3′ end is conserved and its organization resembles the 3′ end of a polyadenylated RNA, suggesting that transcripts of the repeat are involved in the dispersal process either directly or as intermediates in the generation of complementary DNA copies of the sequence. One of the L1 repeats is a recent insertion, since it is found in the Hbbdchromosome, but not in the Hbbschromosome. This suggests a dispersal process that has been active as recently as 4 million years ago.
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影响因子：
14.9
作者：
FANNING, TG
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作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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影响因子：
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作者：
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