Negative mood influences default mode network functional connectivity in patients with chronic low back pain: implications for functional neuroimaging biomarkers.
Negative mood influences default mode network functional connectivity in patients with chronic low back pain: implications for functional neuroimaging biomarkers.
复制标题
DOI：
10.1097/j.pain.0000000000000708
复制
发表时间：
2017-01
期刊：
影响因子：
7.4
通讯作者：
Robinson ME
中科院分区：
文献类型：
--
作者：
Letzen JE;Robinson ME
默认模式网络(DMN)被认为是几种慢性疼痛的生物标志物。DMN功能连接(FcMRI)通常在静息状态fMRI期间进行检查，在此过程中，参与者被指示让思想走动。然而，在数据收集时的因素(例如，负面情绪)可能系统性地影响疼痛感知及其大脑活动，从而影响DMN作为疼痛生物标志物的应用的报道很少。本研究测量了积极和消极情绪是否改变了慢性下腰痛(CLBP)患者的DMN fcMRI模式，特别关注与临床相关的负面情绪。33名参与者(CLBP=17)在悲伤和快乐情绪诱导前后进行了静息状态fMRI扫描，并在扫描时对情绪和疼痛强度进行了评级。对静息状态的功能连通性数据进行双向重复测量方差分析。(CLBP和GT；HC)X状态(悲伤和基线)交互作用在横跨顶盖/中央后回、岛叶皮质、前扣带回、额极和部分小脑的簇中被确定(pFDR<；0.05)。然而，只有一个覆盖部分小脑的显著簇被识别出来，检查幸福的双向重复测量方差分析基线(pFDR<；0.05)。总体而言，这些发现表明，患有和不患有CLBP的个体的DMN fcMRI都受到负面情绪的影响。在慢性疼痛患者中发现的DMN fcMRI可能与疼痛的情感维度有关，这在未来神经成像生物标记物的开发和实施中是重要的考虑因素。
The default mode network (DMN) has been proposed as a biomarker for several chronic pain conditions. DMN functional connectivity (fcMRI) is typically examined during resting-state fMRI, in which participants are instructed to let thoughts wander. However, factors at the time of data collection (e.g., negative mood) that might systematically impact pain perception and its brain activity, influencing the application of the DMN as a pain biomarker, are rarely reported. The present study measured whether positive and negative moods altered DMN fcMRI patterns in chronic low back pain (CLBP) patients, specifically focusing on negative mood due to its clinical-relevance. Thirty-three participants (CLBP = 17) underwent resting-state fMRI scanning before and after sad and happy mood inductions, and rated levels of mood and pain intensity at the time of scanning. Two-way repeated measures ANOVAs were conducted on resting-state functional connectivity data. Significant group (CLBP > HC) X condition (sadness > baseline) interaction effects were identified in clusters spanning parietal operculum/postcentral gyrus, insular cortices, anterior cingulate cortex, frontal pole, and a portion of the cerebellum (pFDR < .05). However, only one significant cluster covering a portion of the cerebellum was identified examining a two-way repeated measures ANOVA for happiness > baseline (pFDR < .05). Overall, these findings suggest that DMN fcMRI is affected by negative mood in individuals with and without CLBP. It is possible that DMN fcMRI seen in chronic pain patients is related to an affective dimension of pain, which is important to consider in future neuroimaging biomarker development and implementation.
登录
查看更多内容
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
4.8
作者：
Gomez-Ramirez J;Wu J
通讯作者：
Wu J
影响因子：
3.2
作者：
Chai XJ;Ofen N;Gabrieli JD;Whitfield-Gabrieli S
通讯作者：
Whitfield-Gabrieli S
影响因子：
5.7
作者：
Craggs, Jason G.;Price, Donald D.;Robinson, Michael M.
通讯作者：
Robinson, Michael M.
影响因子：
3.7
作者：
Eickhoff, SB;Schleicher, A;Amunts, K
通讯作者：
Amunts, K