Reward and executive control network resting-state functional connectivity is associated with impulsivity during reward-based decision making for cocaine users.
Reward and executive control network resting-state functional connectivity is associated with impulsivity during reward-based decision making for cocaine users.
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DOI：
10.1016/j.drugalcdep.2018.09.013
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发表时间：
2019-01-01
影响因子：
4.2
通讯作者：
Meade CS
中科院分区：
文献类型：
--
作者：
Hobkirk AL;Bell RP;Utevsky AV;Huettel S;Meade CS
可卡因成瘾与冲动决策有关，而冲动决策是由涉及奖励处理和执行功能（如认知控制和注意力突出）的大脑回路介导的。在可卡因使用者中，奖赏和执行控制回路之间的静息状态功能连接发生了改变，同时伴有冲动和学习能力的缺陷。先前的研究已经研究了特定的大脑区域如何相互作用来影响吸毒者的冲动决策；然而，研究大规模大脑网络和冲动行为之间的相互作用是有限的。本研究比较了可卡因使用者（n=37）和非可卡因使用者（n=35）的奖励和执行控制网络静息状态功能连通性及其与冲动决策的关系。参与者完成了计算机决策任务和单独的静息状态功能磁共振成像扫描。数据进行独立成分、双重回归和线性回归适度分析。在气球模拟风险任务（BART）中，较高的冲动性与可卡因使用者的左认知控制和亚属前扣带扩展奖励网络之间的反向静息状态连接有关，而对照组则相反。在货币选择问卷中，冲动性较低的控制组的注意显著性和纹状体核心奖励网络之间的正性静息状态连接较强，而可卡因使用者的冲动性和纹状体核心奖励网络之间的静息状态连接没有关联。可卡因使用者表现出奖励-执行控制-静息状态网络耦合与冲动决策之间的异常关联。这些发现支持了这样的结论：奖赏回路和执行控制回路之间的不平衡导致了吸毒时的冲动。
Cocaine addiction is related to impulsive decision making that is mediated by brain circuitry involved in reward processing and executive functions, such as cognitive control and attentional salience. Resting-state functional connectivity between reward and executive control circuitry is altered among cocaine users, with concomitant deficits in impulsivity and learning. Prior research has examined how select brain regions interact to influence impulsive decision making for drug users; however, research examining interactions between large-scale brain networks and impulsive behavior is limited. The current study compared reward and executive control network resting-state functional connectivity and its relationship to impulsive decision making between cocaine users (n=37) and non-cocaine using control participants (n=35). Participants completed computerized decision-making tasks and a separate resting-state functional magnetic resonance imaging scan. Data underwent independent component, dual regression, and linear regression moderation analyses. Higher impulsivity on the Balloon Analogue Risk Task (BART) was associated with inverse resting-state connectivity between the left cognitive control and subgenual anterior cingulate extended reward networks for cocaine users, while the opposite was found for controls. Less impulsivity on the monetary choice questionnaire was associated with stronger positive resting-state connectivity between the attentional salience and striatal core reward networks for controls, while cocaine users showed no association between impulsivity and resting-state connectivity of these networks. Cocaine users show aberrant associations between reward-executive control resting-state network coupling and impulsive decision making. The findings support the conclusion that an imbalance between reward and executive control circuitry contributes to impulsivity in drug use.
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