The plasticity of human maternal brain: longitudinal changes in brain anatomy during the early postpartum period.
The plasticity of human maternal brain: longitudinal changes in brain anatomy during the early postpartum period.
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DOI：
10.1037/a0020884
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发表时间：
2010-10
影响因子：
1.9
通讯作者：
Swain, James E.
中科院分区：
文献类型：
--
作者：
Kim, Pilyoung;Leckman, James F.;Mayes, Linda C.;Feldman, Ruth;Wang, Xin;Swain, James E.
动物研究表明，在产后早期，母体大脑中的结构变化发生在下丘脑、杏仁核、顶叶和前额叶皮层等区域，这些变化与母体行为的表达有关。为了在人类中探索这一点，我们进行了一项前瞻性纵向研究，在产后2-4周和产后3-4个月的两个时间点，使用基于体素的形态测量法对母亲大脑的高分辨率磁共振图像进行灰质变化检查。比较这两个时间点的灰质体积，我们发现前额叶皮层、顶叶和中脑区域的灰质体积增加。中脑（包括下丘脑、黑质和杏仁核）灰质体积的增加与母亲对婴儿的积极看法有关。这些结果表明，人类母性的最初几个月伴随着与母性动机和行为有关的大脑区域的结构变化。
Animal studies suggest that structural changes occur in the maternal brain during the early postpartum period in regions such as the hypothalamus, amygdala, parietal lobe, and prefrontal cortex and such changes are related to the expression of maternal behaviors. In an attempt to explore this in humans, we conducted a prospective longitudinal study to examine gray matter changes using voxel-based morphometry on high resolution magnetic resonance images of mothers’ brains at two time points: 2–4 weeks postpartum and 3–4 months postpartum. Comparing gray matter volumes across these two time points, we found increases in gray matter volume of the prefrontal cortex, parietal lobes, and midbrain areas. Increased gray matter volume in the midbrain including the hypothalamus, substantia nigra, and amygdala was associated with maternal positive perception of her baby. These results suggest that the first months of motherhood in humans are accompanied by structural changes in brain regions implicated in maternal motivation and behaviors.
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