Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet.
Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet.
复制标题
DOI：
10.1016/j.cmet.2013.09.004
复制
发表时间：
2013-10-01
期刊：
影响因子：
29
通讯作者：
de Cabo R
中科院分区：
文献类型：
--
作者：
Jimenez-Gomez Y;Mattison JA;Pearson KJ;Martin-Montalvo A;Palacios HH;Sossong AM;Ward TM;Younts CM;Lewis K;Allard JS;Longo DL;Belman JP;Malagon MM;Navas P;Sanghvi M;Moaddel R;Tilmont EM;Herbert RL;Morrell CH;Egan JM;Baur JA;Ferrucci L;Bogan JS;Bernier M;de Cabo R
肥胖与慢性、低度、全身性炎症有关，这可能会导致胰岛素抵抗和2型糖尿病的发生。白藜芦醇是一种具有抗炎特性的天然化合物，被证明可以改善肥胖小鼠和人类的葡萄糖耐量和胰岛素敏感性。在这里，我们测试了为期2年的白藜芦醇给药对恒河猴白色脂肪组织（WAT）中高脂高糖（HFS）饮食引起的促炎性特征和胰岛素抵抗的影响。80 mg/天白藜芦醇治疗12个月，第二年480 mg/天，减少脂肪细胞大小，增加sirtuin 1表达，减少NF-κB活化，改善内脏而非皮下WAT的胰岛素敏感性。这些效应在3 T3-L1脂肪细胞中重现，这些脂肪细胞在补充有来自喂食HFS +/−白藜芦醇饮食的猴子的血清的培养基中培养。总之，白藜芦醇的长期管理发挥有益的代谢和炎症适应内脏WAT从饮食诱导的肥胖猴子。
Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes. Resveratrol, a natural compound with anti-inflammatory properties, is shown to improve glucose tolerance and insulin sensitivity in obese mice and humans. Here we tested the effect of a 2-year resveratrol administration on pro-inflammatory profile and insulin resistance caused by a high-fat, high-sugar (HFS) diet in white adipose tissue (WAT) from rhesus monkeys. Eighty mg/day of resveratrol for 12-month followed by 480 mg/day for the second year decreased adipocyte size, increased sirtuin 1 expression, decreased NF-κB activation and improved insulin sensitivity in visceral but not subcutaneous WAT from HFS-fed animals. These effects were reproduced in 3T3-L1 adipocytes cultured in media supplemented with serum from monkeys fed HFS +/− resveratrol diets. In conclusion, chronic administration of resveratrol exerts beneficial metabolic and inflammatory adaptations in visceral WAT from diet-induced obese monkeys.
登录
查看更多内容
影响因子：
3.7
作者：
Marchal J;Blanc S;Epelbaum J;Aujard F;Pifferi F
通讯作者：
Pifferi F
影响因子：
5.8
作者：
Ghanim, Husam;Sia, Chang Ling;Dandona, Paresh
通讯作者：
Dandona, Paresh
影响因子：
4.8
作者：
Bogan, Jonathan S.;Rubin, Bradley R.;Cresswell, James A.
通讯作者：
Cresswell, James A.
DOI：
10.1073/pnas.0601752103
发表时间：
2006-04-25
影响因子：
11.1
作者：
Gesta, S;Blüher, M;Kahn, CR
通讯作者：
Kahn, CR
影响因子：
7.7
作者：
Fiori JL;Shin YK;Kim W;Krzysik-Walker SM;González-Mariscal I;Carlson OD;Sanghvi M;Moaddel R;Farhang K;Gadkaree SK;Doyle ME;Pearson KJ;Mattison JA;de Cabo R;Egan JM
通讯作者：
Egan JM