Hypothalamic and dietary control of temperature-mediated longevity.
Hypothalamic and dietary control of temperature-mediated longevity.
复制标题
DOI：
10.1016/j.arr.2009.07.004
复制
发表时间：
2010-01
影响因子：
13.1
通讯作者：
Conti, Bruno
中科院分区：
文献类型：
--
作者：
Tabarean, Iustin;Morrison, Brad;Marcondes, Maria Cecilia;Bartfai, Tamas;Conti, Bruno
温度是变温动物和恒温动物长寿和衰老的重要调节因子。在恒温动物中，温度稳态主要在下丘脑的视前区（POA）中调节。该区域接收并整合外周、中枢和环境信号，并通过调节产热和散热的自主和激素控制来维持几乎恒定的核心体温（Tcore）。在POA中发现的温度敏感神经元被认为是调节这些效应的神经元回路的关键元件。营养平衡也是下丘脑调节的衰老调节剂，也是影响恒温动物Tcore的信号之一。研究下丘脑中营养和温度稳态的调节机制对于理解能量稳态的这两个元素如何影响寿命和衰老以及衰老如何影响下丘脑稳态机制是重要的。
Temperature is an important modulator of longevity and aging in both poikilotherms and homeotherm animals. In homeotherms, temperature homeostasis is regulated primarily in the preoptic area (POA) of the hypothalamus. This region receives and integrates peripheral, central and environmental signals and maintains a nearly constant core body temperature (Tcore) by regulating the autonomic and hormonal control of heat production and heat dissipation. Temperature sensitive neurons found in the POA are considered key elements of the neuronal circuitry modulating these effects. Nutrient homeostasis is also a hypothalamically regulated modulator of aging as well as one of the signals that can influence Tcore in homeotherms. Investigating the mechanisms of the regulation of nutrient and temperature homeostasis in the hypothalamus is important to understand how these two elements of energy homeostasis influence longevity and aging as well as how aging can affect hypothalamic homeostatic mechanisms.
登录
查看更多内容
影响因子：
3.5
作者：
Diem, R;Hobom, M;Bähr, M
通讯作者：
Bähr, M
影响因子：
56.9
作者：
Conti, Bruno;Sanchez-Alavez, Manuel;Bartfai, Tamas
通讯作者：
Bartfai, Tamas
影响因子：
5.5
作者：
BOULANT, JA;HARDY, JD
通讯作者：
HARDY, JD
DOI：
10.1152/ajpregu.1995.269.5.r1250
发表时间：
1995-11-01
影响因子：
2.8
作者：
ALAM, MN;MCGINTY, D;SZYMUSIAK, R
通讯作者：
SZYMUSIAK, R
DOI：
10.1073/pnas.0405775102
发表时间：
2005-02-22
影响因子：
11.1
作者：
Broughton, SJ;Piper, MDW;Partridge, L
通讯作者：
Partridge, L