Multiple genetic programs contribute to CD4 T cell memory differentiation and longevity by maintaining T cell quiescence.
Multiple genetic programs contribute to CD4 T cell memory differentiation and longevity by maintaining T cell quiescence.
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DOI：
10.1016/j.cellimm.2020.104210
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发表时间：
2020-11
影响因子：
4.3
通讯作者：
Sadegh-Nasseri S
中科院分区：
文献类型：
--
作者：
Song N;Sengupta S;Khoruzhenko S;Welsh RA;Kim A;Kumar MR;Sønder SU;Sidhom JW;Zhang H;Jie C;Siliciano RF;Sadegh-Nasseri S
While memory T-cells represent a hallmark of adaptive immunity, little is known about the genetic mechanisms regulating the longevity of memory CD4 T cells. Here, we studied the dynamics of gene expression in antigen specific CD4 T cells during infection, memory differentiation, and long-term survival up to nearly a year in mice. We observed that differentiation into long lived memory cells is associated with increased expression of genes inhibiting cell proliferation and apoptosis as well as genes promoting DNA repair response, lipid metabolism, and insulin resistance. We identified several transmembrane proteins in long-lived murine memory CD4 T cells, which co-localized exclusively within the responding antigen-specific memory CD4 T cells in human. The unique gene signatures of long-lived memory CD4 T cells, along with the new markers that we have defined, will enable a deeper understanding of memory CD4 T cell biology and allow for designing novel vaccines and therapeutics.
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影响因子：
3.6
作者：
Bian A;Neyra JA;Zhan M;Hu MC
通讯作者：
Hu MC
影响因子：
64.8
作者：
BULLER, RML;SMITH, GL;MOSS, B
通讯作者：
MOSS, B
影响因子：
64.8
作者：
Araki, Koichi;Turner, Alexandra P.;Shaffer, Virginia Oliva;Gangappa, Shivaprakash;Keller, Susanne A.;Bachmann, Martin F.;Larsen, Christian P.;Ahmed, Rafi
通讯作者：
Ahmed, Rafi
DOI：
10.1038/nri3567
发表时间：
2014-01
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1196/annals.1398.017
发表时间：
2007-01-01
期刊：
AUTOIMMUNITY, PART A: BASIC PRINCIPLES AND NEW DIAGNOSTIC TOOLS
影响因子：
--
作者：
Gupta, Sudhir;Gollapudi, Sastry
通讯作者：
Gollapudi, Sastry