Data on a novel liver bioscaffold (rDLS) generated from regenerative liver with activated extracellular matrix for functional liver regeneration
Data on a novel liver bioscaffold (rDLS) generated from regenerative liver with activated extracellular matrix for functional liver regeneration
复制标题
由再生肝脏产生的新型肝脏生物支架（rDLS）的数据，具有活化的细胞外基质，用于功能性肝脏再生
DOI：
10.1016/j.dib.2018.07.021
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发表时间：
2018-07
期刊：
影响因子：
1.2
通讯作者：
Lianhua Bai
中科院分区：
文献类型：
--
作者：
Wei Yang;Quanyu Chen;Lianhua Bai
本文中呈现的数据与题为“A novel bioscaffold with naturally-occurring extracellular matrix promotes hepatocyte survival and vessel patency in mouse models of heterogeneous transplantation”（Yang et al.，[1]。本文介绍了一种来源于部分肝切除术肝脏（rDLS）的脱细胞肝脏支架（DLS），与传统的来源于未处理肝脏（nDLS）的支架相比，其支持原代肝细胞存活并促进血液通畅。免疫化学和扫描电子显微镜（SEM）分析表明，血管网络和细胞外基质（ECM）成分与nDLS相似。rDLS体内移植后可防止凝血，免疫荧光染色检测整合素（αIIb、α4）表达，肝移植模型（小鼠、猪）均形成了血容量良好的肝小叶。这些数据表明，具有天然存在的“活化ECM”的新型支架（rDLS）可用于生物工程类器官的体内植入，所述生物工程类器官能够在未来临床中长期发挥功能而不凝血。
The data presented in this article are related to the original research article entitled "A novel bioscaffold with naturally-occurring extracellular matrix promotes hepatocyte survival and vessel patency in mouse models of heterologous transplantation" (Yang et al., in press) [1]. This article describes a decellularized liver scaffold (DLS) that derived from partial hepatectomy liver (rDLS) which supported primary hepatocyte survival and promoted blood patency, as compared with a conventional scaffold that generated from naïve liver (nDLS). Analysis by immunochemistry and scanning electron microscope (SEM) showed that the vessel network and extracellular matrix (ECM) components were similar to the nDLS. The rDLS could prevent blood clotting after transplanted it in vivo, identified by immunofluorescence staining for the integrin (αIIb, α4) expression and liver transplantation models (mice, pigs) a formed well-blood petency liver lobules. These data indicate that the novel scaffold (rDLS) with naturally-occurring "activated ECM" that may be useful for the implantation in vivo of a bioengineered organoid that is able to exert function long term without clotting in future clinic.
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通讯作者：
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一种具有天然细胞外基质的新型生物支架可促进异源移植小鼠模型中的肝细胞存活和血管通畅
影响因子：
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通讯作者：
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