Helminth genomics: The implications for human health.
Helminth genomics: The implications for human health.
复制标题
DOI：
10.1371/journal.pntd.0000538
复制
发表时间：
2009-10-26
影响因子：
3.8
通讯作者：
Lustigman S
中科院分区：
文献类型：
--
作者：
Brindley PJ;Mitreva M;Ghedin E;Lustigman S
超过20亿人（人类的三分之一）感染了寄生蛔虫或扁形虫，统称为蠕虫寄生虫。这些感染引起的疾病造成了巨大的发病率和死亡率，延缓了儿童的身体发育，劳动力丧失了生产力，并使贫穷持续下去。影响人类的主要蠕虫物种的基因组，以及许多其他具有农业和兽医意义的物种的基因组，现在是密集的基因组测序和注释的主题。马来丝虫和两种人类寄生虫日本血吸虫和日本血吸虫的基因组序列草图。mansoni，现在可以买到，除其他外。这些基因组数据将为全面了解蠕虫营养和代谢、宿主依赖性发育和成熟、免疫逃避和进化中所涉及的分子机制提供基础。它们还可能预测新的潜在疫苗候选物和药物靶点。在这篇综述中，我们对这些努力进行了概述，并强调了这些新发现的潜在影响和重要性。
More than two billion people (one-third of humanity) are infected with parasitic roundworms or flatworms, collectively known as helminth parasites. These infections cause diseases that are responsible for enormous levels of morbidity and mortality, delays in the physical development of children, loss of productivity among the workforce, and maintenance of poverty. Genomes of the major helminth species that affect humans, and many others of agricultural and veterinary significance, are now the subject of intensive genome sequencing and annotation. Draft genome sequences of the filarial worm Brugia malayi and two of the human schistosomes, Schistosoma japonicum and S. mansoni, are now available, among others. These genome data will provide the basis for a comprehensive understanding of the molecular mechanisms involved in helminth nutrition and metabolism, host-dependent development and maturation, immune evasion, and evolution. They are likely also to predict new potential vaccine candidates and drug targets. In this review, we present an overview of these efforts and emphasize the potential impact and importance of these new findings.
登录
查看更多内容
影响因子：
4.4
作者：
Gobert GN;Moertel L;Brindley PJ;McManus DP
通讯作者：
McManus DP
影响因子：
3.5
作者：
FRANCO, GR;ADAMS, MD;PENA, SDJ
通讯作者：
PENA, SDJ
TGF-β信号传导控制寄生虫烟瘤曼森的胚胎发育。
影响因子：
6.7
作者：
Freitas TC;Jung E;Pearce EJ
通讯作者：
Pearce EJ
影响因子：
1.5
作者：
Abubucker, Sahar;Martin, John;Mitreva, Makedonka
通讯作者：
Mitreva, Makedonka
影响因子：
4.8
作者：
Faghiri, Zahra;Skelly, Patrick J.
通讯作者：
Skelly, Patrick J.