Antenatal maternal intimate partner violence exposure is associated with sex-specific alterations in brain structure among young infants: Evidence from a South African birth cohort.
Antenatal maternal intimate partner violence exposure is associated with sex-specific alterations in brain structure among young infants: Evidence from a South African birth cohort.
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DOI：
10.1016/j.dcn.2023.101210
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发表时间：
2023-04
影响因子：
4.7
通讯作者：
Halligan, Sarah L.
中科院分区：
文献类型：
--
作者：
Hiscox, Lucy, V;Fairchild, Graeme;Donald, Kirsten A.;Groenewold, Nynke A.;Koen, Nastassja;Roos, Annerine;Narr, Katherine L.;Lawrence, Marina;Hoffman, Nadia;Wedderburn, Catherine J.;Barnett, Whitney;Zar, Heather J.;Stein, Dan J.;Halligan, Sarah L.
母亲在怀孕期间的心理困扰与儿童的不良后果有关，有证据表明性别对大脑发育有特定影响。在这里，我们调查了是否在子宫内暴露于亲密伴侣暴力（IPV），一个特别严重的母亲的压力源，与南非出生队列的婴儿的大脑结构。在妊娠28-32周时测量了143名母亲妊娠期间的IPV暴露，并对婴儿进行了结构和弥散磁共振成像（平均年龄3周）。在IPV暴露（n = 63; 52%女性）和未暴露婴儿（n = 80; 48%女性）之间比较皮质下体积估计值，还在子样本中检查了白色微结构（IPV暴露，n = 28，54%女性;未暴露婴儿，n = 42，40%女性）。在混杂调整分析中，母体IPV暴露与脑容量的性二态效应相关：IPV暴露预测男性尾状核较大，而女性尾状核较小，而男性尾状核较小。在暴露于IPV的雄性动物中，感兴趣的白色物质束内的扩散率变化明显，但雌性动物则不明显。结果是强大的删除母婴对妊娠并发症。需要进一步的研究来了解这些早期的改变是如何与后来在IPV暴露儿童中观察到的神经精神病学结果中的性别偏见联系在一起的。
Maternal psychological distress during pregnancy has been linked to adverse outcomes in children with evidence of sex-specific effects on brain development. Here, we investigated whether in utero exposure to intimate partner violence (IPV), a particularly severe maternal stressor, is associated with brain structure in young infants from a South African birth cohort. Exposure to IPV during pregnancy was measured in 143 mothers at 28–32 weeks’ gestation and infants underwent structural and diffusion magnetic resonance imaging (mean age 3 weeks). Subcortical volumetric estimates were compared between IPV-exposed (n = 63; 52% female) and unexposed infants (n = 80; 48% female), with white matter microstructure also examined in a subsample (IPV-exposed, n = 28, 54% female; unexposed infants, n = 42, 40% female). In confound adjusted analyses, maternal IPV exposure was associated with sexually dimorphic effects in brain volumes: IPV exposure predicted a larger caudate nucleus among males but not females, and smaller amygdala among females but not males. Diffusivity alterations within white matter tracts of interest were evident in males, but not females exposed to IPV. Results were robust to the removal of mother-infant pairs with pregnancy complications. Further research is required to understand how these early alterations are linked to the sex-bias in neuropsychiatric outcomes later observed in IPV-exposed children.
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影响因子：
5.7
作者：
Barkovich MJ;Li Y;Desikan RS;Barkovich AJ;Xu D
通讯作者：
Xu D
影响因子：
25
作者：
Brouwer, Rachel M.;Klein, Marieke;Grasby, Katrina L.;Schnack, Hugo G.;Jahanshad, Neda;Teeuw, Jalmar;Thomopoulos, Sophia I.;Sprooten, Emma;Franz, Carol E.;Gogtay, Nitin;Kremen, William S.;Panizzon, Matthew S.;Olde Loohuis, Loes M.;Whelan, Christopher D.;Aghajani, Moji;Alloza, Clara;Alanaes, Dag;Artiges, Eric;Ayesa-Arriola, Rosa;Barker, Gareth J.;Bastin, Mark E.;Blok, Elisabet;Boen, Erlend;Breukelaar, Isabella A.;Bright, Joanna K.;Buimer, Elizabeth E. L.;Bulow, Robin;Cannon, Dara M.;Ciufolini, Simone;Crossley, Nicolas A.;Damatac, Christienne G.;Dazzan, Paola;de Mol, Casper L.;de Zwarte, Sonja M. C.;Desrivieres, Sylvane;Diaz-Caneja, Covadonga M.;Doan, Nhat Trung;Dohm, Katharina;Froehner, Juliane H.;Goltermann, Janik;Grigis, Antoine;Grotegerd, Dominik;Han, Laura K. M.;Harris, Mathew A.;Hartman, Catharina A.;Heany, Sarah J.;Heindel, Walter;Heslenfeld, Dirk J.;Hohmann, Sarah;Ittermann, Bernd;Jansen, Philip R.;Janssen, Joost;Jia, Tianye;Jiang, Jiyang;Jockwitz, Christiane;Karali, Temmuz;Keeser, Daniel;Koevoets, Martijn G. J. C.;Lenroot, Rhoshel K.;Malchow, Berend;Mandl, Rene C. W.;Medel, Vicente;Meinert, Susanne;Morgan, Catherine A.;Muehleisen, Thomas W.;Nabulsi, Leila;Opel, Nils;de la Foz, Victor Ortiz-Garcia;Overs, Bronwyn J.;Paillere Martinot, Marie-Laure;Redlich, Ronny;Marques, Tiago Reis;Repple, Jonathan;Roberts, Gloria;Roshchupkin, Gennady V.;Setiaman, Nikita;Shumskaya, Elena;Stein, Frederike;Sudre, Gustavo;Takahashi, Shun;Thalamuthu, Anbupalam;Tordesillas-Gutierrez, Diana;van der Lugt, Aad;van Haren, Neeltje E. M.;Wardlaw, Joanna M.;Wen, Wei;Westeneng, Henk-Jan;Wittfeld, Katharina;Zhu, Alyssa H.;Zugman, Andre;Armstrong, Nicola J.;Bonfiglio, Gaia;Bralten, Janita;Dalvie, Shareefa;Davies, Gail;Di Forti, Marta;Ding, Linda;Donohoe, Gary;Forstner, Andreas J.;Gonzalez-Penas, Javier;Guimaraes, Joao P. O. F. T.;Homuth, Georg;Hottenga, Jouke-Jan;Knol, Maria J.;Kwok, John B. J.;Le Hellard, Stephanie;Mather, Karen A.;Milaneschi, Yuri;Morris, Derek W.;Noethen, Markus M.;Papiol, Sergi;Rietschel, Marcella;Santoro, Marcos L.;Steen, Vidar M.;Stein, Jason L.;Streit, Fabian;Tankard, Rick M.;Teumer, Alexander;van 't Ent, Dennis;van der Meer, Dennis;van Eijk, Kristel R.;Vassos, Evangelos;Vazquez-Bourgon, Javier;Witt, Stephanie H.;Adams, Hieab H. H.;Agartz, Ingrid;Ames, David;Amunts, Katrin;Andreassen, Ole A.;Arango, Celso;Banaschewski, Tobias;Baune, Bernhard T.;Belangero, Sintia I.;Bokde, Arun L. W.;Boomsma, Dorret I.;Bressan, Rodrigo A.;Brodaty, Henry;Buitelaar, Jan K.;Cahn, Wiepke;Caspers, Svenja;Cichon, Sven;Crespo-Facorro, Benedicto;Cox, Simon R.;Dannlowski, Udo;Elvsashagen, Torbjorn;Espeseth, Thomas;Falkai, Peter G.;Fisher, Simon E.;Flor, Herta;Fullerton, Janice M.;Garavan, Hugh;Gowland, Penny A.;Grabe, Hans J.;Hahn, Tim;Heinz, Andreas;Hillegers, Manon;Hoare, Jacqueline;Hoekstra, Pieter J.;Ikram, Mohammad A.;Jackowski, Andrea P.;Jansen, Andreas;Jonsson, Erik G.;Kahn, Rene S.;Kircher, Tilo;Korgaonkar, Mayuresh S.;Krug, Axel;Lemaitre, Herve;Malt, Ulrik F.;Martinot, Jean-Luc;McDonald, Colm;Mitchell, Philip B.;Muetzel, Ryan L.;Murray, Robin M.;Nees, Frauke;Nenadic, Igor;Oosterlaan, Jaap;Ophoff, Roel A.;Pan, Pedro M.;Penninx, Brenda W. J. H.;Poustka, Luise;Sachdev, Perminder S.;Salum, Giovanni A.;Schofield, Peter R.;Schumann, Gunter;Shaw, Philip;Sim, Kang;Smolka, Michael N.;Stein, Dan J.;Trollor, Julian N.;van den Berg, Leonard H.;Veldink, Jan H.;Walter, Henrik;Westlye, Lars T.;Whelan, Robert;White, Tonya;Wright, Margaret J.;Medland, Sarah E.;Franke, Barbara;Thompson, Paul M.;Hulshoff Pol, Hilleke E.
通讯作者：
Hulshoff Pol, Hilleke E.
成人自闭症谱系障碍的额叶网络。
DOI：
10.1093/brain/awv351
发表时间：
2016-02
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Catani M;Dell'Acqua F;Budisavljevic S;Howells H;Thiebaut de Schotten M;Froudist-Walsh S;D'Anna L;Thompson A;Sandrone S;Bullmore ET;Suckling J;Baron-Cohen S;Lombardo MV;Wheelwright SJ;Chakrabarti B;Lai MC;Ruigrok AN;Leemans A;Ecker C;Consortium MA;Craig MC;Murphy DG
通讯作者：
Murphy DG
影响因子：
3.7
作者：
Davis, Elysia Poggi;Sandman, Curt A.
通讯作者：
Sandman, Curt A.
影响因子：
5.7
作者：
Bach, Michael;Laun, Frederik B.;Maier-Hein, Klaus H.
通讯作者：
Maier-Hein, Klaus H.