Neurovascular Dysfunction in Diverse Communities With Health Disparities-Contributions to Dementia and Alzheimer's Disease.
Neurovascular Dysfunction in Diverse Communities With Health Disparities-Contributions to Dementia and Alzheimer's Disease.
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DOI：
10.3389/fnins.2022.915405
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发表时间：
2022
影响因子：
4.3
通讯作者：
Nelson, Amy R.
中科院分区：
文献类型：
--
作者：
Saiyasit, Napatsorn;Butlig, Evan-Angelo R.;Chaney, Samantha D.;Traylor, Miranda K.;Hawley, Nanako A.;Randall, Ryleigh B.;Bobinger, Hanna V.;Frizell, Carl A.;Trimm, Franklin;Crook, Errol D.;Lin, Mike;Hill, Benjamin D.;Keller, Joshua L.;Nelson, Amy R.
阿尔茨海默病和相关痴呆症（ADRD）是一个不断扩大的全球性危机。在没有科学突破的情况下，随着更多人的寿命延长，ADRD的全球患病率将继续增加。种族或少数民族群体ADRD的风险和发病率增加，经常被科学研究界忽视。越来越多的证据表明，脑中的血管损伤可引发一系列生物学事件，导致神经变性、认知障碍和ADRD。我们是一群有兴趣发展和扩大ADRD研究的研究人员，重点是血管对痴呆症的贡献，以服务于我们当地的多元化社区。为了实现这一目标，本次审查的主要目的是调查和更好地了解健康的差异在亚拉巴马和健康的社会决定因素的贡献，这些差异，特别是在血管功能障碍的ADRD的背景下。在这里，我们解释了与阿尔茨海默病（AD）相关的神经血管功能障碍以及导致神经血管单位（NVU）功能障碍的内在和外在危险因素。接下来，我们确定居住在亚拉巴马的个体的民族区域健康差异，以及与AD相关的血管危险因素。我们还讨论了目前神经血管功能障碍，轻度认知障碍（MCI）和AD的药物和非药物治疗方案，包括相关研究和正在进行的临床试验。总体而言，个人在亚拉巴马健康的社会和结构性决定因素的不利影响，导致健康差距，农村，少数民族地位，和较低的社会经济地位（SES）。一般来说，这些社区获得医疗保健和健康食品及其他设施的机会有限，导致ADRD早期诊断和药物治疗的机会减少。虽然这篇综述的重点是亚拉巴马州ADRD患者的健康差异的现状，未来的研究必须包括种族，民族和地区的多样性，以最好地能够治疗所有受ADRD影响的个人。
Alzheimer’s disease and related dementias (ADRD) are an expanding worldwide crisis. In the absence of scientific breakthroughs, the global prevalence of ADRD will continue to increase as more people are living longer. Racial or ethnic minority groups have an increased risk and incidence of ADRD and have often been neglected by the scientific research community. There is mounting evidence that vascular insults in the brain can initiate a series of biological events leading to neurodegeneration, cognitive impairment, and ADRD. We are a group of researchers interested in developing and expanding ADRD research, with an emphasis on vascular contributions to dementia, to serve our local diverse community. Toward this goal, the primary objective of this review was to investigate and better understand health disparities in Alabama and the contributions of the social determinants of health to those disparities, particularly in the context of vascular dysfunction in ADRD. Here, we explain the neurovascular dysfunction associated with Alzheimer’s disease (AD) as well as the intrinsic and extrinsic risk factors contributing to dysfunction of the neurovascular unit (NVU). Next, we ascertain ethnoregional health disparities of individuals living in Alabama, as well as relevant vascular risk factors linked to AD. We also discuss current pharmaceutical and non-pharmaceutical treatment options for neurovascular dysfunction, mild cognitive impairment (MCI) and AD, including relevant studies and ongoing clinical trials. Overall, individuals in Alabama are adversely affected by social and structural determinants of health leading to health disparities, driven by rurality, ethnic minority status, and lower socioeconomic status (SES). In general, these communities have limited access to healthcare and healthy food and other amenities resulting in decreased opportunities for early diagnosis of and pharmaceutical treatments for ADRD. Although this review is focused on the current state of health disparities of ADRD patients in Alabama, future studies must include diversity of race, ethnicity, and region to best be able to treat all individuals affected by ADRD.
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影响因子：
2.8
作者：
Alty, Jane;Farrow, Maree;Lawler, Katherine
通讯作者：
Lawler, Katherine
影响因子：
3.9
作者：
Allard, Joanne S.;Ntekim, Oyonumo;Johnson, Steven P.;Ngwa, Julius S.;Bond, Vernon;Pinder, Dynell;Gillum, Richard F.;Fungwe, Thomas V.;Kwagyan, John;Obisesan, Thomas O.
通讯作者：
Obisesan, Thomas O.
DOI：
10.1016/s1474-4422(16)30029-1
发表时间：
2016-08
期刊：
The Lancet. Neurology
影响因子：
--
作者：
Arvanitakis Z;Capuano AW;Leurgans SE;Bennett DA;Schneider JA
通讯作者：
Schneider JA
影响因子：
1.9
作者：
Bailey, TL;Rivara, CB;Hof, PR
通讯作者：
Hof, PR
影响因子：
11.2
作者：
Altmann, Andre;Tian, Lu;Henderson, Victor W.;Greicius, Michael D.
通讯作者：
Greicius, Michael D.