Reflex responses to myocardial ischemia and reperfusion. Role of prostaglandins.
Reflex responses to myocardial ischemia and reperfusion. Role of prostaglandins.
复制标题
对心肌缺血和再灌注的反射反应。
DOI：
10.1161/01.cir.80.6.1878
复制
发表时间：
1989
期刊：
影响因子：
37.8
通讯作者：
Minisi,AJ
中科院分区：
文献类型：
--
作者：
Thames,MD;Minisi,AJ
在人类中，在下壁心肌缺血或梗塞期间以及在缺血区域的血流恢复期间，强有力的血管抑制反射和心脏抑制反射被激活。在狗身上的实验已经证明，这些反应是由于主要位于心脏下壁的传入迷走神经纤维的刺激。前列腺素在心肌缺血期间和可能在再灌注期间释放。前列腺素刺激心室中的化学敏感性而非机械敏感性末梢。我们的研究确定了用吲哚美辛或甲氨蝶呤钠阻断前列腺素合成是否会降低对冠状动脉闭塞和再灌注的反射抑制反应。实验在去窦腹主动脉压力感受器神经后的α-氯醛糖麻醉的狗中进行。闭塞回旋冠状动脉5分钟导致动脉压和肾交感神经活动降低。在释放闭塞后的前5分钟内，肾神经活动仍然受到抑制。在用吲哚美辛（n = 6，5 mg/kg i. v.）或甲氰氨酸钠（n = 3，4 mg/kg i. v.），冠状动脉闭塞导致肾神经活动的抑制显著减少。肾神经活动在再灌注的第一分钟恢复到控制。在另外六个实验中，对冠状动脉闭塞和再灌注的反应没有通过用媒介物处理而改变。我们的数据表明，在心肌缺血和再灌注过程中，洋地黄素作为心室感觉末梢的主要刺激。我们的数据进一步表明，在缺血和再灌注反射抑制反应主要是由于刺激化学敏感的末梢。
Powerful vasodepressor and cardioinhibitory reflexes are activated in humans during inferior wall myocardial ischemia or infarction and during restoration of flow to the ischemic region. Experiments in dogs have demonstrated that these responses are due to stimulation of afferent vagal fibers that are located mainly in the inferior wall of the heart. Prostaglandins are released during myocardial ischemia and possibly during reperfusion. Prostaglandins stimulate chemosensitive but not mechanosensitive endings in the ventricles. Our studies determined whether blockade of prostaglandin synthesis with indomethacin or sodium meclofenamate decreased the reflex inhibitory responses to coronary occlusion and reperfusion. Experiments were done in alpha-chloralose-anesthetized dogs after sinoaortic baroreceptor denervation. Occlusion of the circumflex coronary artery for 5 minutes resulted in decreases in arterial pressure and in renal sympathetic nerve activity. During the first 5 minutes after release of the occlusion, renal nerve activity remained inhibited. After treatment with indomethacin (n = 6, 5 mg/kg i.v.) or sodium meclofenamate (n = 3, 4 mg/kg i.v.), coronary occlusion resulted in significantly less inhibition of renal nerve activity. Renal nerve activity returned to control during the first minute of reperfusion. In six additional experiments the responses to coronary occlusion and reperfusion were not altered by treatment with vehicle. Our data suggest that prostaglandins serve as the major stimulus to ventricular sensory endings during myocardial ischemia and reperfusion. Our data further suggest that reflex inhibitory responses during ischemia and reperfusion are due mainly to stimulation of chemosensitive endings.
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急性心肌缺血和梗塞期间的自主神经失衡
DOI：
10.1007/978-1-4613-3828-4_12
发表时间：
1985
期刊：
The American journal of physiology
影响因子：
--
作者：
M. Thames
通讯作者：
M. Thames
影响因子：
105.7
作者：
WEBB, SW;ADGEY, AAJ;PANTRIDGE, JF
通讯作者：
PANTRIDGE, JF
狗心肌缺血期间肾交感神经活动的反射抑制由左心室受体与迷走神经传入介导。
DOI：
10.1172/jci109315
发表时间：
1979
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
M. Thames;F. Abboud
通讯作者：
F. Abboud
影响因子：
20.1
作者：
FELDER, RB;THAMES, MD
通讯作者：
THAMES, MD
猫冠状动脉闭塞期间，无髓迷走神经传入纤维激活左心室受体。
DOI：
10.1016/0002-9149(76)90422-7
发表时间：
1976
期刊：
The American journal of cardiology
影响因子：
--
作者：
P. Thoren
通讯作者：
P. Thoren