The influence of living near roadways on spirometry and exhaled nitric oxide in elementary schoolchildren.
The influence of living near roadways on spirometry and exhaled nitric oxide in elementary schoolchildren.
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在小学生中，在道路附近生活对肺活量法和呼出一氧化氮的影响。
DOI：
10.1289/ehp.10943
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发表时间：
2008-10
影响因子：
10.4
通讯作者：
Liu L
中科院分区：
文献类型：
--
作者：
Dales R;Wheeler A;Mahmud M;Frescura AM;Smith-Doiron M;Nethery E;Liu L
生活在主要道路附近与呼吸道症状的增加有关，但对这与气道炎症的关系知之甚少。我们根据呼吸功能和气道炎症的客观指标评估了居住在当地居民区附近的影响。我们估计环境空气污染，解决了儿童的邻里水平，使用土地使用回归模型为9-11岁的儿童。我们还计算了每个孩子附近200米半径范围内的道路长度。我们对2,328名儿童进行了空气污染暴露和肺活量测定，并对其中1,613名儿童进行了呼出一氧化氮（eNO）的测量。在家庭半径200米范围内，每公里的当地道路与eNO增加6.8%相关（p = 0.045）。任何类型的道路（当地，主要，高速公路）的每公里也与eNO增加10.1%（p = 0.002）。PM2.5每增加1微克/立方米，eNO增加3.9%（p = 0.058），用力肺活量（FVC）减少0.70%（以预测值的百分比表示）（p = 0.39）。道路密度与1秒用力呼气量和FVC之间的相关性为负，但在p < 0.05时无统计学显著性。如eNO所示，来自当地邻近道路的交通可能导致气道炎症。这可能是一个比传统的净化功能措施更敏感的空气污染不利影响的指标。
Living near major roadways has been associated with an increase in respiratory symptoms, but little is known about how this relates to airway inflammation. We assessed the effects of living near local residential roadways based on objective indicators of ventilatory function and airway inflammation. We estimated ambient air pollution, resolved to the level of the child’s neighborhood, using a land-use regression model for children 9–11 years of age. We also summed the length of roadways found within a 200-m radius of each child’s neighborhood. We had measurements of both air pollution exposure and spirometry for 2,328 children, and also had measurements of exhaled nitric oxide (eNO) for 1,613 of these children. Each kilometer of local roadway within a 200-m radius of the home was associated with a 6.8% increase in eNO (p = 0.045). Each kilometer of any type of roadway (local, major, highway) was also associated with an increase in eNO of 10.1% (p = 0.002). Each microgram per cubic meter increase in PM2.5 was associated with a 3.9% increase in eNO (p = 0.058) and 0.70% decrease in forced vital capacity (FVC) expressed as a percentage of predicted (p = 0.39). Associations between roadway density and both forced expired volume in 1 sec and FVC were negative but not statistically significant at p < 0.05. Traffic from local neighborhood roadways may cause airway inflammation as indicated by eNO. This may be a more sensitive indicator of adverse air pollution effects than traditional measures of ventilatory function.
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影响因子：
10.4
作者：
Koenig, J Q;Jansen, K;Mar, T F;Lumley, T;Kaufman, J;Trenga, C A;Sullivan, J;Liu, L-J S;Shapiro, G G;Larson, T V
通讯作者：
Larson, T V
DOI：
10.1007/s00420-002-0320-x
发表时间：
2002-06-01
影响因子：
3
作者：
Fischer, PH;Steerenberg, PA;van Amsterdam, JGC
通讯作者：
van Amsterdam, JGC
DOI：
10.1164/rccm.200406-710st
发表时间：
2005-04-15
影响因子：
24.7
作者：
American Thoracic Society;European Respiratory Society
通讯作者：
European Respiratory Society
影响因子：
10.4
作者：
Delfino, Ralph J;Staimer, Norbert;Gillen, Dan;Tjoa, Thomas;Sioutas, Constantinos;Fung, Kochy;George, Steven C;Kleinman, Michael T
通讯作者：
Kleinman, Michael T
影响因子：
10.4
作者：
Delfino RJ
通讯作者：
Delfino RJ