The long-term effect of oxandrolone on hepatic acute phase proteins in severely burned children.
The long-term effect of oxandrolone on hepatic acute phase proteins in severely burned children.
复制标题
氧雄龙对严重烧伤儿童肝脏急性期蛋白的长期影响。
DOI：
10.1097/01.ta.0000108636.63225.63
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Herndon,DavidN
中科院分区：
文献类型：
--
作者：
Thomas,Suchmor;Wolf,StevenE;Murphy,KevinD;Chinkes,DavidL;Herndon,DavidN
背景急性时相蛋白的产生是严重烧伤的一个标志。方法35例≥总面积为40%的烧伤患儿随机分为安慰剂组和奥克雄酮组，每日2次，每次0.1 mg/kg，每日2次。分别在入院时、出院时、烧伤后6个月、9个月和12个月测定构成蛋白和急性期蛋白水平。结果与安慰剂组相比，奥曲酮组白蛋白、前白蛋白和视黄醇结合蛋白水平显著升高(p<；0.05)，α1-酸性糖蛋白、补体C3、α-2-巨球蛋白和纤维蛋白原水平显著降低(p<；0.05)。氧胆酮组急性住院期间白蛋白补充量减少。结论严重烧伤患者应用奥昔洛酮治疗后，显著提高了构成蛋白水平，降低了急性期蛋白水平。
BackgroundAcute phase protein production is a hallmark of severe burns. We wondered whether anabolic treatment with oxandrolone would affect these proteins.MethodsThirty-five children with≥ 40% total body surface area burns were randomized to receive either placebo or oxandrolone (0.1 mg/kg by mouth twice daily) from postoperative day 5 to 1 year postburn. Levels of constitutive proteins and acute phase proteins were measured at admission; at discharge; and at 6, 9, and 12 months after burn. Total albumin supplementation and hepatic transaminases were also assessed.ResultsConstitutive proteins such as albumin, prealbumin, and retinol-binding protein levels increased (p< 0.05), and acute phase proteins such as α 1-acid glycoprotein, C3 complement, α 2-macroglobulin, and fibrinogen levels significantly decreased in the oxandrolone group compared with placebo (p< 0.05). Albumin supplementation during the acute hospitalization was reduced in the oxandrolone group. Hepatic transaminases remained within normal levels.ConclusionTreatment with oxandrolone in severe burns significantly increases constitutive protein and reduces acute phase protein levels.
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