Three breakpoints of variant t(2;8) translocations in Burkitt's lymphoma cells fall within a region 140 kilobases distal from c-myc

Three breakpoints of variant t(2;8) translocations in Burkitt's lymphoma cells fall within a region 140 kilobases distal from c-myc
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Burkitt 淋巴瘤细胞中变体 t(2;8) 易位的三个断点位于距 c-myc 140 kilobase 的区域内

DOI:
10.1128/mcb.9.5.2105-2113.1989
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发表时间:
1989
影响因子:
5.3
通讯作者:
Martin Lipp
Martin Lipp
中科院分区:
生物学2区
文献类型:
--
作者:
Berthold;Henglein;lt;Heidi Synovzik;Peter Groitl;G. Bornkamm;Peter Hartl;Martin Lipp

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伯基特淋巴瘤细胞中的变异易位t(2;8)将远离c-myc的8号染色体的q24带连接到Igkappa基因座,在8号染色体上的断点位置具有相当大的变化。我们报告了8号染色体区域的克隆和分子特征,该区域远离c-myc基因座,包括伯基特淋巴瘤细胞系BL 64、BL 21和LY 91在11个重排酶对内的断点,暂时称为bvr-1(伯基特变体重排区1)。利用染色体步移结合脉冲场凝胶电泳获得的c-myc、bvr-1和人pvt-1基因座探针,我们构建了c-myc 3'区的物理图谱。我们绘制了bvr-1和pvt-1分别位于c-myc远端约140和260个酶对。
The variant translocations t(2;8) in Burkitt's lymphoma cells join band q24 of chromosome 8, distal from c-myc, to the Igkappa locus, with considerable variation in the location of the breakpoints on chromosome 8. We report the cloning and molecular characterization of a chromosome 8 region, distal from the c-myc locus, which encompasses the breakpoints of the Burkitt's lymphoma cell lines BL64, BL21, and LY91 within 11 kilobase pairs, termed provisionally bvr-1 (Burkitt's variants' rearranging region 1). Using probes from the c-myc, the bvr-1, and the human pvt-1 loci obtained by chromosome walking coupled with pulsed-field gel electrophoresis, we have constructed a physical map of the region 3' of c-myc. We map bvr-1 and pvt-1 about 140 and 260 kilobase pairs, respectively, distal from c-myc.
DOI: 10.1073/pnas.84.16.5838
发表时间: 1987-08
影响因子: 11.1
作者:
J. Lacy;W. P. Summers;M. Watson;P. Glazer;W. Summers
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发表时间: 1982-01-01
期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
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发表时间: 1986
影响因子: 14.9
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期刊: Cytogenetics and cell genetics
影响因子: --
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