Helicobacter pylori infection progresses proximally associated with pyloric metaplasia in age-dependent tendency: a cross-sectional study.
Helicobacter pylori infection progresses proximally associated with pyloric metaplasia in age-dependent tendency: a cross-sectional study.
复制标题
幽门螺杆菌感染的进展与年龄依赖性幽门化生密切相关：一项横断面研究
DOI：
10.1186/s12876-018-0883-y
复制
发表时间：
2018-10-29
影响因子：
2.4
通讯作者：
Lin R
中科院分区：
文献类型：
--
作者：
Shi H;Xiong H;Qian W;Lin R
研究背景老年人H.近端胃幽门相关疾病。其具体的发病机制尚未明确。H.随着年龄的增长，幽门螺杆菌的定植是动态的。本研究的目的是探讨H.方法将180例有消化不良症状的患者分为青年组、中年组和老年组。从每个患者的五个位置获得活检：大弯（中体，中窦），小弯（中体，中窦）和切迹（IA），分析H。pylori密度、粘膜炎症和组织病理学检查。幽门螺杆菌在胃体部随年龄增长呈线性增加（p 0.001），而在胃窦部和IA无此趋势。螺杆在老年患者中，IA（p = 0.002）和体部（p 0.001）中的幽门密度显著加重，但胃窦中没有。粘膜炎症评分与H.三个年龄组中的幽门螺杆菌定植。老年组幽门腺位于胃体部的比例高于中青年组。H.幽门螺杆菌感染、胃粘膜炎症和胃体幽门化生的发生率随年龄的增加而增加（p0.001）。老年人群中幽门螺杆菌定植和相关炎症。
BackgroundThe elderly population presents higher morbidity of H. pylori associated diseases in proximal stomach. The specific pathogenesis and mechanism have not been clearly addressed. The gastric environment for H. pylori colonization is dynamic with increasing age. The aim of present study is to investigate the correlation among the distribution of H. pylori, mucosal inflammation, gastric microenvironment and age.MethodsA total of 180 patients with dyspepsia symptoms were divided into young, middle-aged and elderly groups. Biopsies were obtained from each patient in five locations: great curvature (mid-corpus, mid-antrum), lesser curvature (mid-corpus, mid-antrum) and incisura angularis (IA), analyzed for H. pylori density, mucosal inflammation and histopathology.ResultsThe infection rate of H. pylori increased linearly with age (p < 0.001) in corpus, but not in antrum and IA. The H. pylori density was significantly aggravated in IA (p = 0.002) and corpus (p < 0.001) in elderly patient, but not in antrum. The mucosa inflammation scores were consistent with the severity of H. pylori colonization among three age groups. In elderly patients, the pyloric glands present more frequently in corpus, comparing with young and middle-aged group. A significant positive correlation among aggravating severity of H. pylori infection, mucosal inflammation and pyloric metaplasia in corpus with increasing age (p < 0.001) was occurred.Conclusions Pyloric metaplasia in corpus was correlated with the risk of aggravated H. pylori colonization and associated inflammation in elderly population.
登录
查看更多内容
胃肠道症状和诊断与幽门螺杆菌感染的风险相关的种族/种族差异。
影响因子：
2.4
作者：
Huerta-Franco MR;Banderas JW;Allsworth JE
通讯作者：
Allsworth JE
影响因子：
4.6
作者：
Radziejewska, Iwona;Borzym-Kluczyk, Malgorzata;Namiot, Zbigniew;Stefanska, Ewa
通讯作者：
Stefanska, Ewa
影响因子：
4.4
作者：
Tomtitchong, Prakitpunthu;Siribumrungwong, Boonying;Chaiyakunapruk, Nathorn
通讯作者：
Chaiyakunapruk, Nathorn
影响因子：
12.6
作者：
Sonnenberg, Amnon;Genta, Robert M.
通讯作者：
Genta, Robert M.
DOI：
10.1111/j.1440-1746.2011.06649.x
发表时间：
2011-04-01
影响因子：
4.1
作者：
Fock, Kwong Ming
通讯作者：
Fock, Kwong Ming