Momordica charantia (Bitter Melon) reduces obesity-associated macrophage and mast cell infiltration as well as inflammatory cytokine expression in adipose tissues.
Momordica charantia (Bitter Melon) reduces obesity-associated macrophage and mast cell infiltration as well as inflammatory cytokine expression in adipose tissues.
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苦瓜（苦瓜）可减少肥胖相关的巨噬细胞和肥大细胞浸润以及脂肪组织中炎症细胞因子的表达
DOI：
10.1371/journal.pone.0084075
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Qu W
中科院分区：
文献类型：
--
作者：
Bao B;Chen YG;Zhang L;Na Xu YL;Wang X;Liu J;Qu W
肥胖是一种世界性的流行病，与2型糖尿病和心血管疾病密切相关。肥胖引起的慢性脂肪组织炎症现在被认为是上述并发症的关键因素。苦瓜(Momordica Charantia，BM)是一种传统的中国食品，以减少体重增加和胰岛素抵抗而闻名。然而，目前还不清楚BM是否可以减轻肥胖引起的脂肪组织炎症。在本研究中，C57BL/6小鼠饲喂高脂饲料(HFD)加或不加BM 12周。含有BM的饮食可以改善高脂饮食引起的肥胖和胰岛素抵抗。组织学和实时荧光定量聚合酶链式反应分析表明，BM不仅减少了巨噬细胞对附睾脂肪组织(EAT)和棕色脂肪组织(BAT)的侵袭。流式细胞仪检测显示，BM可改变EAT巨噬细胞的M1/M2表型比值。进一步的研究表明，BM降低了EAT中肥大细胞的募集，并抑制了EAT和BAT中促炎症细胞因子单核细胞趋化蛋白-1的表达，以及EAT中IL-6和肿瘤坏死因子-α的表达。最后，酶联免疫吸附分析显示，含有BM的饮食也使血清细胞因子水平正常化。总之，在改善胰岛素抵抗和脂肪沉积的同时，BM减少了饮食诱导肥胖(DIO)小鼠的脂肪组织炎症。
Obesity is a world-wide epidemic disease that correlates closely with type 2 diabetes and cardiovascular diseases. Obesity-induced chronic adipose tissue inflammation is now considered as a critical contributor to the above complications. Momordica charantia (bitter melon, BM) is a traditional Chinese food and well known for its function of reducing body weight gain and insulin resistance. However, it is unclear whether BM could alleviate adipose tissue inflammation caused by obesity. In this study, C57BL/6 mice were fed high fat diet (HFD) with or without BM for 12 weeks. BM-contained diets ameliorated HFD-induced obesity and insulin resistance. Histological and real-time PCR analysis demonstrated BM not only reduced macrophage infiltration into epididymal adipose tissues (EAT) and brown adipose tissues (BAT). Flow cytometry show that BM could modify the M1/M2 phenotype ratio of macrophages in EAT. Further study showed that BM lowered mast cell recruitments in EAT, and depressed pro-inflammatory cytokine monocyte chemotactic protein-1 (MCP-1) expression in EAT and BAT as well as interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) expression in EAT. Finally, ELISA analysis showed BM-contained diets also normalized serum levels of the cytokines. In summary, in concert with ameliorated insulin resistance and fat deposition, BM reduced adipose tissue inflammation in diet-induced obese (DIO) mice.
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影响因子：
7.9
作者：
Keller, Amy C.;Ma, Jun;Kavalier, Adam;He, Kan;Brillantes, Anne-Marie B.;Kennelly, Edward J.
通讯作者：
Kennelly, Edward J.
影响因子：
3.7
作者：
Iseli TJ;Turner N;Zeng XY;Cooney GJ;Kraegen EW;Yao S;Ye Y;James DE;Ye JM
通讯作者：
Ye JM
影响因子：
5
作者：
Cheng, Hsueh-Ling;Kuo, Ching-Yi;Lin, Chen-Chen
通讯作者：
Lin, Chen-Chen
影响因子：
2.4
作者：
Gadang, Vidya;Gilbert, William;Devareddy, Latha
通讯作者：
Devareddy, Latha
影响因子：
4.2
作者：
Chen, QX;Chan, LLY;Li, ETS
通讯作者：
Li, ETS