Lateral entorhinal cortex is critical for novel object-context recognition.
Lateral entorhinal cortex is critical for novel object-context recognition.
复制标题
侧向肾上腺皮质对于新颖的对象膜识别至关重要。
DOI：
10.1002/hipo.22095
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发表时间：
2013-05
期刊：
影响因子：
3.5
通讯作者：
Ainge, James A.
中科院分区：
文献类型：
--
作者：
Wilson, David I. G.;Langston, Rosamund F.;Schlesiger, Magdalene I.;Wagner, Monica;Watanabe, Sakurako;Ainge, James A.
情景记忆包含关于特定事件或场合的信息，包括空间位置和事件发生环境的上下文特征。它已经在大鼠中建模，使用自发探索物体的新配置，它们的位置，以及它们所呈现的上下文。虽然我们对空间位置是如何在大脑中处理的有了详细的了解，但对情景记忆中的非空间背景成分是在哪里处理的却知之甚少。最初的实验测量c-fos表达在一个对象上下文识别（OCR）任务，以检查大脑内的网络处理事件的上下文特征。增加c-fos的表达被发现在外侧内嗅皮层（LEC;一个主要的海马传入）在OCR相对于控制条件。在随后的实验中，它被证明，大鼠与病变的LEC不能识别对象的上下文协会，但显示正常的对象识别和正常的上下文识别。这些数据表明，环境的上下文特征与LEC中的对象身份相结合，并表明这种对象上下文关联的识别需要LEC。这是一致的建议，一个事件的上下文功能的处理LEC和这种信息相结合的空间信息从内侧内嗅皮层，形成情节记忆在海马体。© 2013 Wiley Periodicals，Inc.
Episodic memory incorporates information about specific events or occasions including spatial locations and the contextual features of the environment in which the event took place. It has been modeled in rats using spontaneous exploration of novel configurations of objects, their locations, and the contexts in which they are presented. While we have a detailed understanding of how spatial location is processed in the brain relatively little is known about where the nonspatial contextual components of episodic memory are processed. Initial experiments measured c-fos expression during an object-context recognition (OCR) task to examine which networks within the brain process contextual features of an event. Increased c-fos expression was found in the lateral entorhinal cortex (LEC; a major hippocampal afferent) during OCR relative to control conditions. In a subsequent experiment it was demonstrated that rats with lesions of LEC were unable to recognize object-context associations yet showed normal object recognition and normal context recognition. These data suggest that contextual features of the environment are integrated with object identity in LEC and demonstrate that recognition of such object-context associations requires the LEC. This is consistent with the suggestion that contextual features of an event are processed in LEC and that this information is combined with spatial information from medial entorhinal cortex to form episodic memory in the hippocampus. © 2013 Wiley Periodicals, Inc.
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