Helicobacter pylori seropositivity's association with markers of iron, 1-carbon metabolism, and antioxidant status among US adults: a structural equations modeling approach.
Helicobacter pylori seropositivity's association with markers of iron, 1-carbon metabolism, and antioxidant status among US adults: a structural equations modeling approach.
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DOI：
10.1371/journal.pone.0121390
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Zonderman AB
中科院分区：
文献类型：
--
作者：
Beydoun MA;Dore GA;Canas JA;Beydoun HA;Zonderman AB
我们测试了一个模型，其中幽门螺杆菌血清阳性 (Hps) 预测铁状态，铁状态反过来又充当 1-C 代谢标记物的预测因子，然后可以预测抗氧化状态。对全国健康和营养检查调查 (NHANES 1999-2000) 20-85 岁成年人的横断面数据进行了分析 (n = 3,055)。 Hps 标志物、铁状态（血清铁蛋白和转铁蛋白饱和度 (TS)）；将 1-C 代谢（血清叶酸 (FOLserum)、B-12、总同型半胱氨酸 (tHcy)、甲基丙二酸 (MMA)）和抗氧化状态（维生素 A 和 E）输入结构方程模型 (SEM)。 Hps 的预测因素包括年龄较大、教育程度较低、收入较低、种族/族裔群体（非西班牙裔白人中最低）以及终生吸烟。 SEM 模型表明，Hps 与铁状态（结合血清铁蛋白和 TS）呈直接负相关，而铁状态又与 1-C 代谢物（较高的血清叶酸、B-12 或较低的 tHcy/MMA）呈正相关，后者与抗氧化状态（结合血清维生素 A 和 E）呈正相关。发现的另一条途径绕过了 1-C 代谢物（Hps → Iron_st → Antiox）。 Hps 结合模型中的两条途径和其他间接途径（Hps → Iron_st → OneCarbon；Hps →OneCarbon →Antiox）的所有间接影响的总和估计为 β = -0.006±0.003，p<0.05。总之，在幽门螺杆菌血清阳性对抗氧化状态的总体影响中，发现了通过铁状态和 1-碳代谢物的两条重要的间接途径。应进行随机对照试验，以揭示根除幽门螺杆菌对改善幽门螺杆菌血清阳性个体中铁状态、叶酸、B-12 和抗氧化状态的伴随因果效应。
We tested a model in which Helicobacter pylori seropositivity (Hps) predicted iron status, which in turn acted as a predictor for markers of 1-C metabolism that were then allowed to predict antioxidant status. National Health and Nutrition Examination Surveys (NHANES 1999–2000) cross-sectional data among adults aged 20–85 y were analyzed (n = 3,055). Markers of Hps, iron status (serum ferritin and transferrin saturation (TS)); 1-C metabolism (serum folate (FOLserum), B-12, total homocysteine (tHcy), methylmalonic acid (MMA)) and antioxidant status (vitamins A and E) were entered into a structural equations model (SEM). Predictors of Hps included older age, lower education and income, racial/ethnic groups (lowest among Non-Hispanic Whites), and lifetime cigarette smoking. SEM modeling indicated that Hps had a direct inverse relationship with iron status (combining serum ferritin and TS) which in turn was positively related to 1-C metabolites (higher serum folate, B-12 or lower tHcy/MMA) that were positively associated with antioxidant status (combining serum vitamins A and E). Another pathway that was found bypassed 1-C metabolites (Hps → Iron_st → Antiox). The sum of all indirect effects from Hps combining both pathways and the other indirect pathways in the model (Hps → Iron_st → OneCarbon; Hps →OneCarbon →Antiox) was estimated at β = -0.006±0.003, p<0.05. In sum, of the total effect of H. pylori seropositivity on antioxidant status, two significant indirect pathways through Iron status and 1-Carbon metabolites were found. Randomized controlled trials should be conducted to uncover the concomitant causal effect of H. pylori eradication on improving iron status, folate, B-12 and antioxidant status among H. pylori seropositive individuals.
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影响因子：
4.2
作者：
Beydoun, May A.;Shroff, Monal R.;Zonderman, Alan B.
通讯作者：
Zonderman, Alan B.
影响因子：
3.1
作者：
Ding, Song-Ze;Minohara, Yutaka;Crowe, Sheila E.
通讯作者：
Crowe, Sheila E.
影响因子：
9.3
作者：
Ellervik, Christina;Tybjaerg-Hansen, Anne;Nordestgaard, Borge G.
通讯作者：
Nordestgaard, Borge G.
影响因子：
168.9
作者：
BAYERDORFFER, E;NEUBAUER, A;STOLTE, M
通讯作者：
STOLTE, M
影响因子：
3.6
作者：
DiGirolamo, Ann M.;Perry, Geraldine S.;Grummer-Strawn, Laurence M.
通讯作者：
Grummer-Strawn, Laurence M.