Longitudinal changes over three years in sex steroid hormone levels in women aged 70 years and over.
Longitudinal changes over three years in sex steroid hormone levels in women aged 70 years and over.
复制标题
70岁及以上女性性类固醇激素水平三年的纵向变化
DOI：
10.1111/cen.14401
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发表时间：
2021-03
影响因子：
3.2
通讯作者：
ASPREE Investigator Group
中科院分区：
文献类型：
--
作者：
Islam RM;Bell RJ;Handelsman DJ;Robinson PJ;Wolfe R;Davis SR;ASPREE Investigator Group
女性的性类固醇水平随着年龄的增长而变化，从70岁（70+）开始。这是否反映了个体随年龄的变化或生存优势尚不清楚。本研究旨在确定70岁以上个体女性中循环性类固醇和SHBG随时间的稳定性。前瞻性队列研究。400名年龄70岁以上的女性，未使用任何性类固醇、抗雄激素/雌激素或糖皮质激素治疗。性类固醇浓度，通过液相色谱-串联质谱法和性激素结合球蛋白（SHBG）通过免疫测定法测定，在配对的血液样本中抽取3年，并一起分析。400名女性，中位（IQR）年龄78.0（8.6）岁，被纳入分析。随访样本的平均睾酮浓度在统计学上显著高于基线水平。变化是适度的（平均变化31 pmol/L，95%置信区间（CI）2.4-59.8; p = 0.034），并没有在所有女性中观察到增加。平均体重指数在统计学上显著下降（平均变化-0.4 kg/m2，95% CI 0.6--0.3; p < .001），平均血清SHBG浓度显著增加（平均变化4.0 nmol/L，95% CI 2.7-5.4; p < .001）。观察到的睾酮变化不能用观察到的SHBG变化来解释。平均雌酮或脱氢表雄酮浓度无显著变化。70岁以上女性中的睾酮浓度更可能增加而不是减少。是否增加睾酮浓度的老年妇女赋予生存优势需要调查。
Sex steroid levels in women vary with increasing age from the age of 70 years (70+). Whether this reflects change within individuals with age or a survival advantage is not known. This study aimed to determine the stability of circulating sex steroids and SHBG over time in individual women aged 70+. A prospective cohort study. 400 women, aged 70+ not using any sex steroid, anti-androgen/oestrogen or glucocorticoid therapy. Sex steroid concentrations, measured by liquid chromatography-tandem mass spectrometry and sex hormone-binding globulin (SHBG) by immunoassay, in paired blood samples drawn 3 years apart and analysed together. 400 women, median (IQR) age 78.0 (8.6) years, were included in the analysis. Mean testosterone concentrations were statistically significantly higher in follow-up samples compared with baseline. The change was modest (mean change 31 pmol/L, 95% confidence interval (CI) 2.4-59.8; p = .034), and an increase was not observed in all women. There was a statistically significant decline in mean body mass index (mean change −0.4 kg/m2, 95% CI 0.6 to −0.3; p < .001) and a significant increase in the mean serum SHBG concentration (mean change 4.0 nmol/L, 95% CI 2.7-5.4; p < .001). The change observed in testosterone was not explained by the observed change in SHBG. There was no significant change in the mean oestrone or dehydroepiandrosterone concentration. Testosterone concentrations in women aged 70+ were more likely to increase than decrease. Whether increasing testosterone concentrations in older women confer a survival advantage needs investigation.
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影响因子：
3.4
作者：
KATZ, S;AKPOM, CA
通讯作者：
AKPOM, CA
影响因子：
5.8
作者：
Cappola, Anne R.;Ratcliffe, Sarah J.;Fried, Linda P.
通讯作者：
Fried, Linda P.
影响因子：
5.8
作者：
Skiba, Marina A.;Bell, Robin J.;Davis, Susan R.
通讯作者：
Davis, Susan R.
影响因子：
9.9
作者：
Drake, EB;Henderson, VW;Buckwalter, JG
通讯作者：
Buckwalter, JG
影响因子：
5.8
作者：
Rariy, Chevon M.;Ratcliffe, Sarah J.;Cappola, Anne R.
通讯作者：
Cappola, Anne R.