Pericyte dynamics during angiogenesis: new insights from new identities.
Pericyte dynamics during angiogenesis: new insights from new identities.
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DOI：
10.1159/000362276
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发表时间：
2014
影响因子：
1.7
通讯作者：
Murfee WL
中科院分区：
文献类型：
--
作者：
Stapor PC;Sweat RS;Dashti DC;Betancourt AM;Murfee WL
旨在操纵微循环的疗法需要控制血管生成的能力，血管生成的定义是从现有血管长出新的毛细血管。在多种疾病(癌症、视网膜病变、类风湿性关节炎)中，阻断血管生成将是有益的。在其他方面(心肌梗塞、中风、高血压)，促进血管生成将是可取的。我们知道血管周细胞在内皮细胞周围延伸，在功能上与调节血管稳定、血管直径和内皮细胞增殖有关。在血管生成过程中，周细胞-内皮细胞双向信号转导对毛细血管芽的形成至关重要。周细胞引导毛细血管发芽的观察也暗示了它们在内皮细胞引导中的作用。因此，周细胞最近已成为促进或抑制血管生成的治疗靶点。推进我们对周细胞的基本理解和开发周细胞相关疗法的能力，就像在许多其他领域一样，受到关于细胞身份的问题的挑战。这篇综述文章讨论了我们对周细胞表型的了解，以及通过定义参与毛细血管萌发的特定周细胞群体来促进我们对周细胞的理解的机会。
Therapies aimed at manipulating the microcirculation require the ability to control angiogenesis, defined as the sprouting of new capillaries from existing vessels. In multiple pathologies (cancer, retinopathies, rheumatoid arthritis), blocking angiogenesis would be beneficial. In others (myocardial infarction, stroke, hypertension), promoting angiogenesis would be desirable. We know vascular pericytes elongate around endothelial cells and are functionally associated with regulating vessel stabilization, vessel diameter, and endothelial cell proliferation. During angiogenesis, bidirectional pericyte-endothelial cell signaling is critical for capillary sprout formation. Observations of pericytes leading capillary sprouts also implicate their role in endothelial cell guidance. As such, pericytes have recently emerged as a therapeutic target to promote or inhibit angiogenesis. Advancing our basic understanding of pericytes and the ability to develop pericyte-related therapies are challenged, like in many other fields, by questions regarding cell identity. This review article discusses what we know about pericyte phenotypes and the opportunity to advance our understanding of pericytes by defining specific pericyte cell populations involved in capillary sprouting.
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影响因子：
--
作者：
Ganguly A;Yang H;Cabral F
通讯作者：
Cabral F
影响因子：
50.3
作者：
Cooke VG;LeBleu VS;Keskin D;Khan Z;O'Connell JT;Teng Y;Duncan MB;Xie L;Maeda G;Vong S;Sugimoto H;Rocha RM;Damascena A;Brentani RR;Kalluri R
通讯作者：
Kalluri R
影响因子：
4
作者：
Bertani, N;Malatesta, P;Perris, R
通讯作者：
Perris, R
影响因子：
8.3
作者：
Foudah D;Redondo J;Caldara C;Carini F;Tredici G;Miloso M
通讯作者：
Miloso M
影响因子：
3.3
作者：
Fukushi, J;Makagiansar, IT;Stallcup, WB
通讯作者：
Stallcup, WB