Association of Sleep Duration, Symptoms, and Disorders with Mortality in Adults with Chronic Kidney Disease.
Association of Sleep Duration, Symptoms, and Disorders with Mortality in Adults with Chronic Kidney Disease.
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DOI：
10.1016/j.ekir.2017.05.002
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发表时间：
2017-09
影响因子：
6
通讯作者：
Lash JP
中科院分区：
文献类型：
--
作者：
Ricardo AC;Goh V;Chen J;Cedillo-Couvert E;Kapella M;Prasad B;Parvathaneni S;Knutson K;Lash JP
在一般人群中，睡眠时间短或长、睡眠质量差和睡眠障碍与死亡风险增加有关。我们评估了CKD患者的这些关联性。这是一项前瞻性队列研究，研究对象为2005年至2008年间的1452名慢性肾脏病患者。慢性肾脏病的定义是估计肾小球滤过率为每1.73m2 60毫升/分钟或尿白蛋白/肌酐比值为≥30 mg/g。自我报告睡眠时间、睡眠症状(入睡困难、入睡困难、日间嗜睡和非恢复性睡眠)和睡眠障碍(不宁腿综合征和睡眠呼吸暂停)。生命状态是使用NHANES死亡链接确定的，截止日期为2011年12月31日。在这个队列中，平均年龄为61岁，58%是女性，75%是非西班牙裔白人。在4.4年的中位随访期间，我们观察到234例死亡，其中75例死于心血管原因。在多变量分析中，与报告睡眠时间为7至8小时的个体相比，睡眠时间为7小时和8小时的全因死亡率的HR(95%CI)分别为1.50(1.08-2.10)和1.36(0.89-2.08)。心血管病死率(95%CI)分别为1.56(0.72~3.37)和1.56(0.66~3.65)。非恢复性睡眠和不宁腿综合征增加了全因死亡率(HR，1.63[95%CI，1.13-2.35]和HR，1.69[95%CI，1.04-275])。在患有CKD的成年人中，睡眠时间短、非恢复性睡眠和不宁腿综合征与死亡风险增加相关。这些发现强调了促进CKD患者充足睡眠的重要性，以及未来评估睡眠干预对这一人群影响的必要性。
In general populations, short and long sleep duration, poor sleep quality, and sleep disorders have been associated with increased risk of death. We evaluated these associations in individuals with CKD. This was a prospective cohort study of 1452 NHANES 2005 to 2008 participants with CKD. CKD was defined by estimated glomerular filtration rate <60 ml/min per 1.73 m2 or urine albumin-to-creatinine ratio ≥30 mg/g. Sleep duration, sleep symptoms (difficulty falling asleep, difficulty staying asleep, daytime sleepiness, and nonrestorative sleep), and sleep disorders (restless legs syndrome and sleep apnea) were self-reported. Vital status was determined using NHANES mortality linkage through December 31, 2011. In this cohort, the mean age was 61 years, 58% were women, and 75% non-Hispanic white. During 4.4 years of median follow-up, we observed 234 deaths, of which 75 were due to cardiovascular causes. In multivariable analyses, compared with individuals who reported 7 to 8 hours of sleep, HR (95% CI) for all-cause mortality for sleep duration <7 hours and >8 hours were 1.50 (1.08–2.10) and 1.36 (0.89–2.08), respectively. The corresponding HR (95% CI) for cardiovascular mortality were 1.56 (0.72–3.37) and 1.56 (0.66–3.65). Nonrestorative sleep and restless legs syndrome were associated with increased risk for all-cause mortality (HR, 1.63 [95% CI, 1.13–2.35], and HR, 1.69 [95% CI, 1.04–275], respectively). In adults with CKD, short sleep duration, nonrestorative sleep, and restless legs syndrome are associated with increased risk of death. These findings underscore the importance of promoting adequate sleep in patients with CKD, and the need for future studies evaluating the impact of sleep interventions in this population.
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影响因子：
--
作者：
Marcheva, Biliana;Ramsey, Kathryn M;Peek, Clara B;Affinati, Alison;Maury, Eleonore;Bass, Joseph
通讯作者：
Bass, Joseph
DOI：
10.1056/nejmoa1114248
发表时间：
2012-07-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Inker LA;Schmid CH;Tighiouart H;Eckfeldt JH;Feldman HI;Greene T;Kusek JW;Manzi J;Van Lente F;Zhang YL;Coresh J;Levey AS;CKD-EPI Investigators
通讯作者：
CKD-EPI Investigators
影响因子：
19.6
作者：
McMullan CJ;Curhan GC;Forman JP
通讯作者：
Forman JP
影响因子：
16.2
作者：
Cappuccio FP;D'Elia L;Strazzullo P;Miller MA
通讯作者：
Miller MA
影响因子：
5.6
作者：
Chasens, Eileen R.;Ratcliffe, Sarah J.;Weaver, Terri E.
通讯作者：
Weaver, Terri E.