Comparison of radiation dermatitis between hypofractionated and conventionally fractionated postoperative radiotherapy: objective, longitudinal assessment of skin color.
Comparison of radiation dermatitis between hypofractionated and conventionally fractionated postoperative radiotherapy: objective, longitudinal assessment of skin color.
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DOI：
10.1038/s41598-018-30710-4
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发表时间：
2018-08-17
影响因子：
4.6
通讯作者：
Yamada K
中科院分区：
文献类型：
--
作者：
Yamazaki H;Takenaka T;Aibe N;Suzuki G;Yoshida K;Nakamura S;Masui K;Kimoto T;Sasaki N;Nishimura T;Nakashima A;Goto M;Yamada K
本研究旨在定量比较保乳手术后接受术后放疗的患者中低分割（Hypo）和常规分割（Conv）外照射放疗引起的放射性皮炎。皮肤颜色的变化，在L*（亮度，白-黑），a*（红-绿），和B*（黄-蓝）的价值，由于外部光束放疗，在交替的分数使用客观的方法进行了检查。Hypo组26例（42.56戈伊/16次），Conv组46例（50戈伊/25次）。放射治疗使L* 值逐渐降低（变深），a* 值逐渐升高（变红）。这些颜色变化的进展呈线性，根据流逝的分数，并在低和Conv每部分之间是相似的。Hypo组的L* 和a* 值的变化显著轻于Conv组。最大剂量与L* 和a* 值的变化显著相关。不良事件通用术语标准v4评估未显示低血糖组（0：1：2 = 2：24：1）和常规组（1：39：6，p = 0.25）之间存在统计学显著差异。我们的客观分析结果显示，接受Hypo治疗的患者比接受Conv治疗的患者显示出更轻微的颜色改变，并且最大剂量是颜色改变的有用预测因素。
This study aimed to quantitatively compare radiation dermatitis due to hypofractionated (Hypo) and conventionally fractionated (Conv) external-beam radiotherapy in patients who underwent postoperative radiotherapy after breast-conserving surgery. Skin color changes, in terms of L* (brightness, white-black), a* (red-green), and b* (yellow-blue) values, due to external-beam radiotherapy were examined at alternate fractions using an objective method. Twenty-six patients were included in the Hypo group (42.56 Gy/16 fractions) and 46 in the Conv group (50 Gy/25 fractions). Radiotherapy decreased the L* value (darker) and increased the a* value (redder) gradually. These color alterations progressed linearly according to elapsed fractions and were similar between Hypo and Conv per fraction. The Hypo group showed significantly milder alterations in L* and a* values than the Conv group. The maximal dosage was significantly correlated to alterations in L* and a* values. Common Terminology Criteria for Adverse Events v4 assessment did not show a statistically significant difference between the Hypo (Grade 0:1:2 = 2:24:1) and Conv (1:39:6, p = 0.25) groups. The results of our objective analysis revealed that patients undergoing Hypo show milder color alteration than those undergoing Conv and that the maximal dosage is a useful predicator of color alteration.
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影响因子：
3.8
作者：
Chen MF;Chen WC;Lai CH;Hung CH;Liu KC;Cheng YH
通讯作者：
Cheng YH
DOI：
10.1186/1748-717x-8-57
发表时间：
2013-03-12
期刊：
Radiation oncology (London, England)
影响因子：
--
作者：
Di Franco R;Sammarco E;Calvanese MG;De Natale F;Falivene S;Di Lecce A;Giugliano FM;Murino P;Manzo R;Cappabianca S;Muto P;Ravo V
通讯作者：
Ravo V
DOI：
10.1186/1748-717x-7-217
发表时间：
2012-12-18
期刊：
Radiation oncology (London, England)
影响因子：
--
作者：
Kraus-Tiefenbacher U;Sfintizky A;Welzel G;Simeonova A;Sperk E;Siebenlist K;Mai S;Wenz F
通讯作者：
Wenz F
影响因子：
3.9
作者：
Huang, Chih-Jen;Hou, Ming-Feng;Chuang, Hung-Yi
通讯作者：
Chuang, Hung-Yi
DOI：
10.1016/s0360-3016(97)00292-7
发表时间：
1997-08-01
影响因子：
7
作者：
Buchholz, TA;Gurgoze, E;Prestidge, BR
通讯作者：
Prestidge, BR