Testicular responses to hCG stimulation at varying doses in men with spinal cord injury.
Testicular responses to hCG stimulation at varying doses in men with spinal cord injury.
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DOI：
10.1038/sc.2017.8
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发表时间：
2017-07
期刊：
影响因子：
2.2
通讯作者：
Spungen AM
中科院分区：
文献类型：
--
作者：
Bauman WA;La Fountaine MF;Cirnigliaro CM;Kirshblum SC;Spungen AM
前瞻性测试睾丸的挑衅性刺激是否可以识别患有慢性脊髓损伤（SCI）的男性，该人群的血清睾酮浓度经常降低，可能是由于性腺功能障碍所致。为了实现这一目标，施用常规剂量和低于常规剂量的人绒毛膜促性腺激素（hCG）。 30 名患有慢性 SCI 的男性 [受伤时间 > 1 年； 18岁至65岁；该研究招募了 16 名性腺功能正常 (>12.1 nmol/l) 和 14 名性腺功能减退 (≤12.1 nmol/l)] 或身体健全 (AB) 男性 [11 名性腺功能正常和 27 名性腺功能减退]。进行刺激试验以量化睾丸对三种剂量浓度（即 400 IU、2000 IU 和 4000 IU）肌内注射 hCG 的反应。连续两天注射 hCG，并在两次注射前的清晨采血检测血清睾酮；受试者在第 3 天返回进行最终的血液样本采集。 SCI 组和 AB 组对每个剂量 hCG 的平均性腺反应在性腺功能减退或性腺正常受试者中没有显着差异，所有组中的平均血清睾酮浓度均显示出足够的反应。这项工作证实了原发性睾丸功能障碍的存在，并且没有证明用低于常规剂量的 hCG 对睾丸进行激发刺激有额外的益处。我们的研究结果支持了先前的研究，即大多数 SCI 和血清睾酮浓度降低的患者会出现继发性睾丸功能障碍。
Prospective To test whether provocative stimulation of the testes identifies men with chronic spinal cord injury (SCI), a population in which serum testosterone concentrations are often depressed, possibility due to gonadal dysfunction. To accomplish this objective, conventional and lower than the conventional doses of human chorionic gonadotropin (hCG) were administered. Thirty men with chronic SCI [duration of injury >1 year; 18 and 65 years old; 16 eugonadal (>12.1 nmol/l) and 14 hypogonadal (≤12.1 nmol/l)] or able-bodied (AB) men [11 eugonadal and 27 hypogonadal] were recruited for the study. Stimulation tests were performed to quantify testicular responses to the intramuscular administration of hCG at three dose concentrations (i.e., 400 IU, 2000 IU, and 4000 IU). The hCG was administered on two consecutive days and blood was collected for serum testosterone in the early morning prior to each of two injections; subjects returned on day 3 for a final blood sample collection. The average gonadal response in the SCI and AB groups to each dose of hCG was not significantly different in the hypogonadal or eugonadal subjects, with the mean serum testosterone concentrations in all groups demonstrating an adequate response. This work confirmed the absence of primary testicular dysfunction without additional benefit demonstrated of provocative stimulation of the testes with lower than conventional doses of hCG. Our findings support prior work that suggested a secondary testicular dysfunction occurs in a majority of those with SCI and depressed serum testosterone concentrations.
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DOI：
10.1177/1533317514556874
发表时间：
2015-06-01
影响因子：
3.4
作者：
Cherrier, M. M.;Anderson, K.;Matsumoto, A. M.
通讯作者：
Matsumoto, A. M.
影响因子：
3.3
作者：
Friedl, KE;Moore, RJ;Askew, EW
通讯作者：
Askew, EW
DOI：
10.1097/phm.0b013e3181837f4f
发表时间：
2008-09-01
影响因子：
3
作者：
Clark, Mary J.;Schopp, Laura H.;Acuff, Michael E.
通讯作者：
Acuff, Michael E.
影响因子：
9.8
作者：
HUANG, TS;WANG, YH;LIEN, YN
通讯作者：
LIEN, YN
影响因子：
5.8
作者：
GRAY, A;FELDMAN, HA;LONGCOPE, C
通讯作者：
LONGCOPE, C