GOLM1-regulated EGFR/RTK recycling is a novel target for combating HCC metastasis
GOLM1-regulated EGFR/RTK recycling is a novel target for combating HCC metastasis
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GOLM1调节的EGFR/RTK回收是对抗HCC转移的新靶点
DOI：
10.1007/s11427-016-0311-x
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发表时间：
2016-11
期刊：
影响因子：
--
通讯作者：
Qin LX
中科院分区：
文献类型：
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作者：
Zhu Wenwei;Qin Lunxiu;Qin LX
A salient feature of metastasis is the ability of different tumor types to colonize the same or different organ sites. Many genetic and epigenetic events have been identified that contributing to the metastatic cascades, including migration, local invasion, intravasation, survival in the circulation, extravasation and colonization, and some key molecules might have dual functions promoting metastasis by providing both local advantage from malignant progression in the primary tumor and a distal advantage from infiltration of distant organs. Nevertheless, the metastatic process remains poorly understood and the insight into the molecular events that initiate and/or sustain this process remains incomplete. The Golgi apparatus-complex is a highly dynamic organelle which is considered the “heart” of intracellular transportation. It has been demonstrated to play an active role in cell migration through posttranslational modification; and prominent changes in Golgi apparatus, with disruption at biochemical composition, structure and function levels, have been observed in human carcinogenesis and metastasis (Wlodkowic et al., 2009). The important cancer-specific hallmarks of Golgi include the aberrant glycosylation and abnormal expression of Ras GTPases, as well as dysregulation of cell migration (Wlodkowic et al., 2009). While fragmentation of the Golgi was confirmed in cancer by electron microscopy almost fifty years ago, it is only in recent years that we have begun to understand the significance of Golgi
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GOLM1 调节 EGFR/RTK 细胞表面回收以驱动肝细胞癌转移。
影响因子：
50.3
作者：
Ye QH;Zhu WW;Zhang JB;Qin Y;Lu M;Lin GL;Guo L;Zhang B;Lin ZH;Roessler S;Forgues M;Jia HL;Lu L;Zhang XF;Lian BF;Xie L;Dong QZ;Tang ZY;Wang XW;Qin LX
通讯作者：
Qin LX
影响因子：
64.8
作者：
Scott, Kenneth L.;Kabbarah, Omar;Liang, Mei-Chih;Ivanova, Elena;Anagnostou, Valsamo;Wu, Joyce;Dhakal, Sabin;Wu, Min;Chen, Shujuan;Feinberg, Tamar;Huang, Joseph;Saci, Abdel;Widlund, Hans R.;Fisher, David E.;Xiao, Yonghong;Rimm, David L.;Protopopov, Alexei;Wong, Kwok-Kin;Chin, Lynda
通讯作者：
Chin, Lynda
影响因子：
2.7
作者：
Wlodkowic D;Skommer J;McGuinness D;Hillier C;Darzynkiewicz Z
通讯作者：
Darzynkiewicz Z
影响因子：
3.5
作者：
Kladney RD;Bulla GA;Guo L;Mason AL;Tollefson AE;Simon DJ;Koutoubi Z;Fimmel CJ
通讯作者：
Fimmel CJ
DOI：
10.1038/nrm2748
发表时间：
2009-09
期刊：
Nature reviews. Molecular cell biology
影响因子：
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作者：
通讯作者：
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