Exposure to airborne polycyclic aromatic hydrocarbons during pregnancy and risk of preterm birth.
Exposure to airborne polycyclic aromatic hydrocarbons during pregnancy and risk of preterm birth.
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在怀孕期间暴露于空气中的多环芳烃和早产风险。
DOI：
10.1016/j.envres.2014.09.014
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发表时间：
2014-11
影响因子：
8.3
通讯作者：
Shaw, Gary M.
中科院分区：
文献类型：
--
作者：
Padula, Amy M.;Noth, Elizabeth M.;Hammond, S. Katharine;Lurmann, Fred W.;Yang, Wei;Tager, Ira B.;Shaw, Gary M.
早产是健康的重要标志，在美国的患病率为12-13%。多环芳烃（PAHs）是一组有机污染物，在碳氢化合物不完全燃烧过程中形成，如煤、柴油和汽油。研究表明，怀孕期间接触多环芳烃与不良的出生结果有关。本研究的目的是评估怀孕期间接触多环芳烃与早产之间的关系。研究人群包括2001-2006年出生的妇女，其母亲居住地在加州弗雷斯诺主要监测点20公里范围内。研究人员利用弗雷斯诺地区的数据建立了一个时空模型，对研究地区所有新生儿在怀孕期间在母亲住所每天暴露于4、5或6环的多环芳烃进行了分配。从出生证明中提取出生胎龄和相关协变量。我们发现怀孕最后6周的多环芳烃与20-27周的分娩之间存在关联（OR=2.74; 95% CI: 2.24-3.34），将最高的四分位数与最低的三分位数进行比较。当每个四分位数比较最低时，这种关联是一致的（or2 =1.49, 95% CI: 1.08-2.06; or3 =2.63, 95% CI:1.93-3.59; or4 =3.94, 95% CI:3.03-5.12）。在整个妊娠期和妊娠早期以及28-31周和20-27周分娩期间暴露于多环芳烃也观察到负相关。观察到产前6周多环芳烃暴露与早期早产之间的关系。然而，与早期早产的负相关提供了一个不明确的，潜在的复杂的，这些关联的推断。
Preterm birth is an important marker of health and has a prevalence of 12-13% in the U.S. Polycyclic aromatic hydrocarbons (PAHs) are a group of organic contaminants that form during the incomplete combustion of hydrocarbons, such as coal, diesel and gasoline. Studies suggest that exposure to PAHs during pregnancy is related to adverse birth outcomes. The aim of this study is to evaluate the association between exposure to PAHs during the pregnancy and preterm birth. The study population included births from years 2001-2006 of women whose maternal residence was within 20 km of the primary monitoring site in Fresno, California. Data in the Fresno area were used to form a spatio-temporal model to assign daily exposure to PAHs with 4, 5, or 6 rings at the maternal residence throughout pregnancy of all of the births in the study area. Gestational age at birth and relevant covariates were extracted from the birth certificate. We found an association between PAHs during the last 6 weeks of pregnancy and birth at 20-27 weeks (OR=2.74; 95% CI: 2.24-3.34) comparing the highest quartile to the lower three. The association was consistent when each quartile was compared to the lowest (OR2nd=1.49, 95% CI: 1.08-2.06; OR3rd=2.63, 95% CI:1.93-3.59; OR4th=3.94, 95% CI:3.03-5.12). Inverse associations were also observed for exposure to PAHs during the entire pregnancy and the first trimester and birth at 28-31 weeks and 20-27 weeks. An association between PAH exposure during the 6 weeks before delivery and early preterm birth was observed. However, the inverse association with early preterm birth offers an unclear, and potentially complex, inference of these associations.
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