Relationship Between Magnetic Resonance Imaging Features and Knee Pain Over Six Years in Knees Without Radiographic Osteoarthritis at Baseline.
Relationship Between Magnetic Resonance Imaging Features and Knee Pain Over Six Years in Knees Without Radiographic Osteoarthritis at Baseline.
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DOI：
10.1002/acr.24394
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发表时间：
2021-11
影响因子：
4.7
通讯作者：
Englund M
中科院分区：
文献类型：
--
作者：
Magnusson K;Turkiewicz A;Kumm J;Zhang F;Englund M
探讨提示膝骨关节炎（OA）的磁共振成像（MRI）特征是否与早期OA发展中可能出现的膝关节疼痛相关。我们纳入了来自骨关节炎倡议的294名参与者（平均±SD年龄50±3岁；50%为女性），基线双膝kelgren /Lawrence评分为0，所有参与者在6年内（基线、24、48和72个月）的4个不同时间点接受了膝关节mri。使用线性混合模型（个体内膝关节匹配），我们研究了MRI特征(半月板体挤压[毫米]，软骨面积损失[评分0-39]，软骨全层损失[评分0-16]，骨赘[评分0-29]，半月板完整性[评分0-10]，骨髓病变[bls]包括骨髓囊肿[评分0-20]，Hoffa -或积液-滑膜炎[缺席/存在]，膝关节损伤和骨关节炎结局评分（oos）问卷采用0-100分（从最差到最好）报告，腘窝囊肿[缺席/存在]与膝关节特异性疼痛相关。MRI评分高1个单位的膝关节的oos膝关节疼痛评分差异如下：半月板挤压-1.52(95%可信区间[95% CI] -2.35, -0.69)；软骨面积损失-0.23 (95% CI -0.48, 0.02)；软骨全层损失-1.04 (95% CI -1.58, -0.50)；骨赘-0.32 (95% CI -0.61, -0.03)；半月板完整性-0.28 (95% CI -0.58, 0.02)；包括潜在囊肿的脑损伤-0.19 (95% CI -0.55, 0.16)；滑膜炎0.23 (95% CI -1.14, 1.60)；腘窝囊肿0.86 （95% CI -0.56, 2.29）。半月板挤压、全层软骨缺损和骨赘与膝关节疼痛加重有关。虽然这些特征可能是未来试验的相关目标，但我们的研究结果的临床相关性尚不清楚，因为没有特征与膝关节疼痛的临床重要差异相关。
To explore whether magnetic resonance imaging (MRI) features suggestive of knee osteoarthritis (OA) are associated with presence of knee pain in possible early‐stage OA development. We included 294 participants from the Osteoarthritis Initiative (mean ± SD age 50 ± 3 years; 50% women) with baseline Kellgren/Lawrence grade of 0 in both knees, all of whom had received knee MRIs at 4 different time points over 6 years (baseline, 24, 48, and 72 months). Using a linear mixed model (knees matched within individuals), we studied whether MRI features (meniscal body extrusion [in mm], cartilage area loss [score 0–39], cartilage full thickness loss [range 0–16], osteophytes [range 0–29], meniscal integrity [range 0–10], bone marrow lesions [BMLs] including bone marrow cysts [range 0–20], Hoffa‐ or effusion‐synovitis [absent/present], and popliteal cysts [absent/present]) were associated with knee‐specific pain as reported on the Knee Injury and Osteoarthritis Outcome Score (KOOS) questionnaire using a 0–100 scale (worst to best). The differences in KOOS knee pain score for a knee with a 1 unit higher score on MRI were the following: meniscal extrusion –1.52 (95% confidence interval [95% CI] –2.35, –0.69); cartilage area loss –0.23 (95% CI –0.48, 0.02); cartilage full thickness loss –1.04 (95% CI –1.58, –0.50); osteophytes –0.32 (95% CI –0.61, –0.03); meniscal integrity –0.28 (95% CI –0.58, 0.02); BMLs including potential cysts –0.19 (95% CI –0.55, 0.16); synovitis 0.23 (95% CI –1.14, 1.60); and popliteal cysts 0.86 (95% CI –0.56, 2.29). Meniscal extrusion, full thickness cartilage loss, and osteophytes are associated with having more knee pain. Although these features may be relevant targets for future trials, the clinical relevance of our findings is unclear because no feature was associated with a clinically important difference in knee pain.
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影响因子：
4.7
作者：
Baum, Thomas;Joseph, Gabby B.;Arulanandan, Ahilan;Nardo, Lorenzo;Virayavanich, Warapat;Carballido-Gamio, Julio;Nevitt, Michael C.;Lynch, John;McCulloch, Charles E.;Link, Thomas M.
通讯作者：
Link, Thomas M.
影响因子：
7
作者：
MacFarlane, L. A.;Yang, H.;Katz, J. N.
通讯作者：
Katz, J. N.
影响因子：
19.7
作者：
Kumm, Jaanika;Roemer, Frank W.;Englund, Martin
通讯作者：
Englund, Martin
影响因子：
--
作者：
Englund, Martin;Guermazi, Ali;Roemer, Frank W.;Aliabadi, Piran;Yang, Mei;Lewis, Cora E.;Torner, James;Nevitt, Michael C.;Sack, Burton;Felson, David T.
通讯作者：
Felson, David T.
影响因子：
2
作者：
Begg, MD;Parides, MK
通讯作者：
Parides, MK