Fluctuations in tumor blood flow under normotension and the effect of angiotensin II-induced hypertension.
Fluctuations in tumor blood flow under normotension and the effect of angiotensin II-induced hypertension.
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DOI：
10.1111/j.1349-7006.1991.tb01797.x
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发表时间：
1991-11
期刊：
影响因子：
--
通讯作者：
Zhang QH
中科院分区：
文献类型：
--
作者：
Hori K;Suzuki M;Tanda S;Saito S;Shinozaki M;Zhang QH
为了阐明血管紧张素II （AID）诱导的高血压化疗的意义，我们用氢气清除率法测量了正常皮下和肿瘤组织血流量（AH109A, LY80）的变化。一种新开发的麻醉机被用来保持动物的状态不变。正常皮下及肿瘤组织血流量在正常血压下随时间波动。在两种不同类型的肿瘤中，肿瘤木流的性质和波动速率几乎相同。然而，当同时测量这些不同组织的血流量时，肿瘤和正常皮下的血流量波动几乎总是呈负相关，即当正常皮下组织血流量减少时，肿瘤血流量增加，反之亦然。研究结果支持了肿瘤血管床与正常血管床的连接模式为平行回路的观点。在All‐诱导的高血压下，正常血管床的血管阻力似乎大于正常血压下的血管阻力，因为All‐增加的肿瘤血流量总是超过正常血压下的最大肿瘤血流量。由于肿瘤血流的波动，在正常血压条件下，肿瘤内无血流或低血流区域会零星地移动，从而抵抗抗癌药物的输送。然而，All‐诱导的高血压诱导了良好的药物递送到肿瘤组织的条件。
To elucidate the significance of angiotensin II (AID‐induced hypertension chemotherapy, changes of tissue blood flow both in normal subcutis and in tumors (AH109A, LY80) were measured with the hydrogen gas clearance method. A newly‐developed anesthetic machine was used to keep the animals' condition constant. Tissue blood flow in normal subcutis and tumors always fluctuated with time under normotension. The nature and the rate of fluctuation in tumor Wood flow were almost identical in two different types of tumors. However, the fluctuation of blood flow in tumor and that in normal subcutis were almost always inversely related when blood flows in these different tissues were measured simultaneously, i.e., when tissue blood flow in normal subcutis decreased, tumor blood flow increased, and vice versa. The findings supported the idea that the connection mode between the tumor vascular bed and normal vascular bed is a parallel circuit. Vascular resistance in the normal vascular bed under All‐induced hypertension seemed to be greater than that under normotension, because the All‐increased tumor blood flow always exceeded the maximum tumor blood flow under normotension. Due to the fluctuations of tumor blood flow, no‐flow or low‐flow areas, resistant to delivery of anti‐cancer drugs, moved sporadically within the tumor under the normotensive condition. However, good conditions for drug delivery to tumor tissue were induced by All‐induced hypertension.
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影响因子：
15.9
作者：
KETY, SS;SCHMIDT, CF
通讯作者：
SCHMIDT, CF
影响因子：
2.6
作者：
BROWN, JM
通讯作者：
BROWN, JM
影响因子：
--
作者：
Chambers, R;Zwetifach, BW
通讯作者：
Zwetifach, BW
DOI：
10.1093/jnci/72.1.145
发表时间：
1984-01-01
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
CHAN, RC;BABBS, CF;LAMAR, CH
通讯作者：
LAMAR, CH
影响因子：
3.4
作者：
MENKE, H;VAUPEL, P
通讯作者：
VAUPEL, P